Aristolochene synthase

In enzymology, an aristolochene synthase (EC number|4.2.3.9) is an enzyme that catalyzes the chemical reaction

:2-trans,6-trans-farnesyl diphosphate $ightleftharpoons$ aristolochene + diphosphate

Hence, this enzyme has one substrate, 2-trans,6-trans-farnesyl diphosphate, and two products, aristolochene and diphosphate.

This enzyme belongs to the family of lyases, specifically those carbon-oxygen lyases acting on phosphates. The systematic name of this enzyme class is 2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, aristolochene-forming). Other names in common use include sesquiterpene cyclase, trans,trans-farnesyl diphosphate aristolochene-lyase, trans,trans-farnesyl-diphosphate diphosphate-lyase (cyclizing,, and aristolochene-forming). This enzyme participates in terpenoid biosynthesis.

tructural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes PDB link|2E4O and PDB link|2OA6. They are both notable for the very high helix content of the structure.

References

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External links

Gene Ontology (GO) codes