3-hydroxypalmitoyl-(acyl-carrier-protein) dehydratase

3-hydroxypalmitoyl-(acyl-carrier-protein) dehydratase

In enzymology, a 3-hydroxypalmitoyl- [acyl-carrier-protein] dehydratase (EC number|4.2.1.61) is an enzyme that catalyzes the chemical reaction

:(3R)-3-hydroxypalmitoyl- [acyl-carrier-protein] ightleftharpoons hexadec-2-enoyl- [acyl-carrier-protein] + H2O

Hence, this enzyme has one substrate, [(3R)-3-hydroxypalmitoyl- [acyl-carrier-protein] , and two products, [hexadec-2-enoyl- [acyl-carrier-protein] and H2O.

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is (3R)-3-hydroxypalmitoyl- [acyl-carrier-protein] hydro-lyase (hexadec-2-enoyl- [acyl-carrier protein] -forming). Other names in common use include D-3-hydroxypalmitoyl- [acyl-carrier-protein] dehydratase, beta-hydroxypalmitoyl-acyl carrier protein dehydrase, beta-hydroxypalmitoyl thioester dehydratase, beta-hydroxypalmityl-ACP dehydrase, and (3R)-3-hydroxypalmitoyl- [acyl-carrier-protein] hydro-lyase. This enzyme participates in fatty acid biosynthesis.

tructural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code PDB link|2PFF.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9030-86-8."

Gene Ontology (GO) codes


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