Phosphopantothenoylcysteine decarboxylase

In enzymology, a phosphopantothenoylcysteine decarboxylase (EC number|4.1.1.36) is an enzyme that catalyzes the chemical reaction

:N- [(R)-4'-phosphopantothenoyl] -L-cysteine $ightleftharpoons$ pantotheine 4'-phosphate + CO₂

Hence, this enzyme has one substrate, [N- [(R)-4'-phosphopantothenoyl] -L-cysteine] , and two products, pantotheine 4'-phosphate and CO₂.

This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is N- [(R)-4'-phosphopantothenoyl] -L-cysteine carboxy-lyase (pantotheine-4'-phosphate-forming). Other names in common use include 4-phosphopantotheoylcysteine decarboxylase, 4-phosphopantothenoyl-L-cysteine decarboxylase, PPC-decarboxylase, and N- [(R)-4'-phosphopantothenoyl] -L-cysteine carboxy-lyase. This enzyme participates in pantothenate and coa biosynthesis.

tructural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1MVL, PDB link|1MVN, and PDB link|1QZU.

References

*
*

External links

::"The CAS registry number for this enzyme class is CAS registry|9024-69-5."

Gene Ontology (GO) codes