Isocitrate lyase

Isocitrate lyase

In enzymology, an isocitrate lyase (EC number|4.1.3.1) is an enzyme that catalyzes the chemical reaction

:isocitrate ightleftharpoons succinate + glyoxylate

Hence, this enzyme has one substrate, isocitrate, and two products, succinate and glyoxylate.

This enzyme belongs to the family of lyases, specifically the oxo-acid-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is isocitrate glyoxylate-lyase (succinate-forming). Other names in common use include isocitrase, isocitritase, isocitratase, threo-Ds-isocitrate glyoxylate-lyase, and isocitrate glyoxylate-lyase. This enzyme participates in glyoxylate and dicarboxylate metabolism.

tructural studies

As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1DQU, PDB link|1F61, PDB link|1F8I, PDB link|1F8M, and PDB link|1IGW.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9045-78-7."

Gene Ontology (GO) codes


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