Dimethylaniline-N-oxide aldolase

Dimethylaniline-N-oxide aldolase
dimethylaniline-N-oxide aldolase
Identifiers
EC number 4.1.2.24
CAS number 37290-58-7
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a dimethylaniline-N-oxide aldolase (EC 4.1.2.24) is an enzyme that catalyzes the chemical reaction

N,N-dimethylaniline N-oxide \rightleftharpoons N-methylaniline + formaldehyde

Hence, this enzyme has one substrate, N,N-dimethylaniline N-oxide, and two products, N-methylaniline and formaldehyde.

This enzyme belongs to the family of lyases, specifically the aldehyde-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is N,N-dimethylaniline-N-oxide formaldehyde-lyase (N-methylaniline-forming). Other names in common use include microsomal oxidase II, microsomal N-oxide dealkylase, and N,N-dimethylaniline-N-oxide formaldehyde-lyase.

References

  • Machinist JM, Orme-Johnson WH, Ziegler DM (1966). "Microsomal oxidases. II. Properties of a pork liver microsomal N-oxide dealkylase". Biochemistry. 5 (9): 2939–43. doi:10.1021/bi00873a025. PMID 5961882. 
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