Arylmalonate decarboxylase

Arylmalonate decarboxylase
arylmalonate decarboxylase
Identifiers
EC number 4.1.1.76
CAS number 144713-36-0
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, an arylmalonate decarboxylase (EC 4.1.1.76) is an enzyme that catalyzes the chemical reaction

2-aryl-2-methylmalonate \rightleftharpoons 2-arylpropanoate + CO2

Hence, this enzyme has one substrate, 2-aryl-2-methylmalonate, and two products, 2-arylpropanoate and CO2.

This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 2-aryl-2-methylmalonate carboxy-lyase (2-arylpropanoate-forming). Other names in common use include AMDASE, 2-aryl-2-methylmalonate carboxy-lyase, and 2-aryl-2-methylmalonate carboxy-lyase (2-arylpropionate-forming).

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2DGD.

References

  • Miyamoto K, Ohta H (1992). "Cloning and heterologous expression of a novel arylmalonate decarboxylase gene from Alcaligenes bronchisepticus KU 1201". Appl. Microbiol. Biotechnol. 38 (2): 234–8. PMID 1369144. 
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