2,2-dialkylglycine decarboxylase (pyruvate)

In enzymology, a 2,2-dialkylglycine decarboxylase (pyruvate) (EC number|4.1.1.64) is an enzyme that catalyzes the chemical reaction

:2,2-dialkylglycine + pyruvate $ightleftharpoons$ dialkyl ketone + CO₂ + L-alanine

Thus, the two substrates of this enzyme are 2,2-dialkylglycine and pyruvate, whereas its 3 products are dialkyl ketone, CO₂, and L-alanine.

This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 2,2-dialkylglycine carboxy-lyase (amino-transferring L-alanine-forming). Other names in common use include dialkyl amino acid (pyruvate) decarboxylase, alpha-dialkyl amino acid transaminase, 2,2-dialkyl-2-amino acid-pyruvate aminotransferase, L-alanine-alpha-ketobutyrate aminotransferase, dialkylamino-acid decarboxylase (pyruvate), and 2,2-dialkylglycine carboxy-lyase (amino-transferring). It employs one cofactor, pyridoxal phosphate.

tructural studies

As of late 2007, 16 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1D7R, PDB link|1D7S, PDB link|1D7U, PDB link|1D7V, PDB link|1DGD, PDB link|1DGE, PDB link|1DKA, PDB link|1M0N, PDB link|1M0O, PDB link|1M0P, PDB link|1M0Q, PDB link|1Z3Z, PDB link|1ZC9, PDB link|1ZOB, PDB link|1ZOD, and PDB link|2DKB.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9032-17-1."

Gene Ontology (GO) codes