DDT-dehydrochlorinase

DDT-dehydrochlorinase
DDT-dehydrochlorinase
Identifiers
EC number 4.5.1.1
CAS number 9031-20-3
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a DDT-dehydrochlorinase (EC 4.5.1.1) is an enzyme that catalyzes the chemical reaction

1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane \rightleftharpoons 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene + chloride

Hence, this enzyme has one substrate, 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane, and two products, 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene and chloride.

This enzyme belongs to the family of lyases, specifically the class of carbon-halide lyases. The systematic name of this enzyme class is 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane chloride-lyase [1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene-forming]. Other names in common use include DDT-ase, 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane chloride-lyase, and DDTase. This enzyme participates in 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane (ddt) and [[]].

References

  • LIPKE H, KEARNS CW (1959). "DDT dehydrochlorinase. I. Isolation, chemical properties, and spectrophotometric assay". J. Biol. Chem. 234 (8): 2123–8. PMID 13673024. 
  • LIPKE H, KEARNS CW (1959). "DDT dehydrochlorinase. II. Substrate and cofactor specificity". J. Biol. Chem. 234 (8): 2129–32. PMID 13673025. 
  • Moorefield HH (1956). "Purification of DDT-dehydrochlorinase from resistant houseflies". Contr. Boyce Thompson Inst. 18: 303–310. 
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