1-aminocyclopropane-1-carboxylate synthase

In enzymology, a 1-aminocyclopropane-1-carboxylate synthase (EC number|4.4.1.14) is an enzyme that catalyzes the chemical reaction

:S-adenosyl-L-methionine $ightleftharpoons$ 1-aminocyclopropane-1-carboxylate + methylthioadenosine

Hence, this enzyme has one substrate, S-adenosyl-L-methionine, and two products, 1-aminocyclopropane-1-carboxylate and methylthioadenosine.

This enzyme belongs to the family of lyases, specifically carbon-sulfur lyases. The systematic name of this enzyme class is S-adenosyl-L-methionine methylthioadenosine-lyase (1-aminocyclopropane-1-carboxylate-forming). Other names in common use include 1-aminocyclopropanecarboxylate synthase, 1-aminocyclopropane-1-carboxylic acid synthase, 1-aminocyclopropane-1-carboxylate synthetase, aminocyclopropanecarboxylic acid synthase, aminocyclopropanecarboxylate synthase, ACC synthase, and S-adenosyl-L-methionine methylthioadenosine-lyase. This enzyme participates in propanoate metabolism. It employs one cofactor, pyridoxal phosphate.

tructural studies

As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1B8G, PDB link|1IAX, PDB link|1IAY, PDB link|1M4N, PDB link|1M7Y, and PDB link|1YNU.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|72506-68-4."

Gene Ontology (GO) codes