Isochorismatase

Isochorismatase

In enzymology, an isochorismatase (EC number|3.3.2.1) is an enzyme that catalyzes the chemical reaction

:isochorismate + H2O ightleftharpoons 2,3-dihydroxy-2,3-dihydrobenzoate + pyruvate

Thus, the two substrates of this enzyme are isochorismate and H2O, whereas its two products are 2,3-dihydroxy-2,3-dihydrobenzoate and pyruvate.

This enzyme belongs to the family of hydrolases, specifically those acting on ether bonds (ether hydrolases). The systematic name of this enzyme class is isochorismate pyruvate-hydrolase. Other names in common use include 2,3-dihydro-2,3-dihydroxybenzoate synthase, 2,3-dihydroxy-2,3-dihydrobenzoate synthase, and 2,3-dihydroxy-2,3-dihydrobenzoic synthase. This enzyme participates in the biosynthesis of siderophore group (nonribosomal).

tructural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1NF8, PDB link|1NF9, and PDB link|2FQ1.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|37288-64-5."

Gene Ontology (GO) codes


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