N-acylglucosamine 2-epimerase

N-acylglucosamine 2-epimerase
N-acylglucosamine 2-epimerase
Identifiers
EC number 5.1.3.8
CAS number 37318-34-6
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a N-acylglucosamine 2-epimerase (EC 5.1.3.8) is an enzyme that catalyzes the chemical reaction

N-acyl-D-glucosamine \rightleftharpoons N-acyl-D-mannosamine

Hence, this enzyme has one substrate, N-acyl-D-glucosamine, and one product, N-acyl-D-mannosamine.

This enzyme belongs to the family of isomerases, specifically those racemases and epimerases acting on carbohydrates and derivatives. The systematic name of this enzyme class is N-acyl-D-glucosamine 2-epimerase. Other names in common use include acylglucosamine 2-epimerase, and N-acetylglucosamine 2-epimerase. This enzyme participates in aminosugars metabolism. It employs one cofactor, ATP.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1FP3.

References

  • Ghosh S and Roseman S (1965). "The sialic acids. V. N-Acyl-D-glucosamine 2-epimerase". J. Biol. Chem. 240: 1531–1536. PMID 14285488. 
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