Muconolactone Delta-isomerase

muconolactone delta-isomerase
Identifiers
EC number	5.3.3.4
CAS number	37318-46-0
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles

In enzymology, a muconolactone Delta-isomerase (EC 5.3.3.4) is an enzyme that catalyzes the chemical reaction

(S)-5-oxo-2,5-dihydrofuran-2-acetate $\rightleftharpoons$ 5-oxo-4,5-dihydrofuran-2-acetate

Hence, this enzyme has one substrate, (S)-5-oxo-2,5-dihydrofuran-2-acetate, and one product, 5-oxo-4,5-dihydrofuran-2-acetate.

This enzyme belongs to the family of isomerases, specifically those intramolecular oxidoreductases transposing C=C bonds. The systematic name of this enzyme class is 5-oxo-4,5-dihydrofuran-2-acetate Delta3-Delta2-isomerase. This enzyme is also called muconolactone isomerase. This enzyme participates in benzoate degradation via hydroxylation.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1MLI.

References

• Ornston LN (1966). "The conversion of catechol and protocatechuate to beta-ketoadipate by Pseudomonas putida. 3. Enzymes of the catechol pathway". J. Biol. Chem. 241 (16): 3795–9. PMID 5330966. 
• Ornston LN (1970). "Conversion of catechol and protocatechuate to beta-ketoadipate (Pseudomonas putida)". Methods Enzymol. 17A: 529–549.