Maleate isomerase

Maleate isomerase
maleate isomerase
Identifiers
EC number 5.2.1.1
CAS number 9023-74-9
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a maleate isomerase (EC 5.2.1.1) is an enzyme that catalyzes the chemical reaction

maleate \rightleftharpoons fumarate

Hence, this enzyme has one substrate, maleate, and one product, fumarate.

This enzyme belongs to the family of isomerases, specifically cis-trans isomerases. The systematic name of this enzyme class is maleate cis-trans-isomerase. This enzyme participates in butanoate metabolism and nicotinate and nicotinamide metabolism.

References

  • Behrmann EJ, Stanier RY (1957). "The bacterial oxidation of nicotinic acid". J. Biol. Chem. 228 (2): 923–45. PMID 13475371. 
  • Scher W, Jakoby WB (1969). "Maleate isomerase". J. Biol. Chem. 244 (7): 1878–82. PMID 5780844. 
  • Hatakeyama K, Asai Y, Uchida Y, Kobayashi M, Terasawa M, Yukawa H (1997). "Gene cloning and characterization of maleate cis-trans isomerase from Alcaligenes faecalis". Biochem. Biophys. Res. Commun. 239 (1): 74–9. doi:10.1006/bbrc.1997.7430. PMID 9345272. 
  • Hatakeyama K, Goto M, Uchida Y, Kobayashi M, Terasawa M, Yukawa H (2000). "Molecular analysis of maleate cis-trans isomerase from thermophilic bacteria". Biochem. Biophys. Res. Commun. 64 (3): 569–76. doi:10.1271/bbb.64.569. PMID 10803955. 
  • Fisch F, Fleites CM, Delenne M, Baudendistel N, Hauer B, Turkenburg JP, Hart S, Bruce NC, Grogan G (2010). "A covalent succinylcysteine-like intermediate in the enzyme-catalyzed transformation of maleate to fumarate by maleate isomerase". J. Am. Chem. Soc. 132 (33): 11455–7. doi:10.1021/ja1053576. PMID 20677745. 
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