- Dichloromuconate cycloisomerase
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dichloromuconate cycloisomerase Identifiers EC number 5.5.1.11 CAS number 126904-95-8 Databases IntEnz IntEnz view BRENDA BRENDA entry ExPASy NiceZyme view KEGG KEGG entry MetaCyc metabolic pathway PRIAM profile PDB structures RCSB PDB PDBe PDBsum Gene Ontology AmiGO / EGO Search PMC articles PubMed articles In enzymology, a dichloromuconate cycloisomerase (EC 5.5.1.11) is an enzyme that catalyzes the chemical reaction
- 2,4-dichloro-2,5-dihydro-5-oxofuran-2-acetate 2,4-dichloro-cis,cis-muconate
Hence, this enzyme has one substrate, 2,4-dichloro-2,5-dihydro-5-oxofuran-2-acetate, and one product, 2,4-dichloro-cis,cis-muconate.
This enzyme belongs to the family of isomerases, specifically the class of intramolecular lyases. The systematic name of this enzyme class is 2,4-dichloro-2,5-dihydro-5-oxofuran-2-acetate lyase (decyclizing). This enzyme participates in 1,4-dichlorobenzene degradation. It employs one cofactor, manganese.
References
- Kuhm AE, Schlomann M, Knackmuss HJ, Pieper DH (1990). "Purification and characterization of dichloromuconate cycloisomerase from Alcaligenes eutrophus JMP 134". Biochem. J. 266 (3): 877–83. PMC 1131220. PMID 2327971. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1131220.
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