- Chloromuconate cycloisomerase
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chloromuconate cycloisomerase Identifiers EC number 5.5.1.7 CAS number 95990-33-3 Databases IntEnz IntEnz view BRENDA BRENDA entry ExPASy NiceZyme view KEGG KEGG entry MetaCyc metabolic pathway PRIAM profile PDB structures RCSB PDB PDBe PDBsum Gene Ontology AmiGO / EGO Search PMC articles PubMed articles In enzymology, a chloromuconate cycloisomerase (EC 5.5.1.7) is an enzyme that catalyzes the chemical reaction
- 2-chloro-2,5-dihydro-5-oxofuran-2-acetate
3-chloro-cis,cis-muconate
Hence, this enzyme has one substrate, 2-chloro-2,5-dihydro-5-oxofuran-2-acetate, and one product, 3-chloro-cis,cis-muconate.
This enzyme belongs to the family of isomerases, specifically the class of intramolecular lyases. The systematic name of this enzyme class is 2-chloro-2,5-dihydro-5-oxofuran-2-acetate lyase (decyclizing). This enzyme is also called muconate cycloisomerase II. This enzyme participates in gamma-hexachlorocyclohexane degradation and 1,4-dichlorobenzene degradation. It employs one cofactor, manganese.
Structural studies
As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1CHR, 1NU5, and 2CHR.
References
- Schmidt E, Knackmuss HJ (1980). "Chemical structure and biodegradability of halogenated aromatic compounds. Conversion of chlorinated muconic acids into maleoylacetic acid". Biochem. J. 192 (1): 339–47. PMC 1162339. PMID 7305906. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1162339.
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