TAF6

TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa, also known as TAF6, is a human gene.

PBB_Summary
section_title =
summary_text = Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the smaller subunits of TFIID that binds weakly to TBP but strongly to TAF1, the largest subunit of TFIID. Four isoforms have been identified but complete transcripts have been determined for only three isoforms. One of the isoforms has been shown to preclude binding of one of the other TFIID subunits, thereby reducing transcription and initiating signals that trigger apoptosis.cite web | title = Entrez Gene: TAF6 TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6878| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Klemm RD, Goodrich JA, Zhou S, Tjian R |title=Molecular cloning and expression of the 32-kDa subunit of human TFIID reveals interactions with VP16 and TFIIB that mediate transcriptional activation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 13 |pages= 5788–92 |year= 1995 |pmid= 7597030 |doi=
*cite journal | author=Chen HI, Sudol M |title=The WW domain of Yes-associated protein binds a proline-rich ligand that differs from the consensus established for Src homology 3-binding modules. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 17 |pages= 7819–23 |year= 1995 |pmid= 7644498 |doi=
*cite journal | author=Hisatake K, Ohta T, Takada R, "et al." |title=Evolutionary conservation of human TATA-binding-polypeptide-associated factors TAFII31 and TAFII80 and interactions of TAFII80 with other TAFs and with general transcription factors. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 18 |pages= 8195–9 |year= 1995 |pmid= 7667268 |doi=
*cite journal | author=Zhou Q, Sharp PA |title=Novel mechanism and factor for regulation by HIV-1 Tat. |journal=EMBO J. |volume=14 |issue= 2 |pages= 321–8 |year= 1995 |pmid= 7835343 |doi=
*cite journal | author=Parada CA, Yoon JB, Roeder RG |title=A novel LBP-1-mediated restriction of HIV-1 transcription at the level of elongation in vitro. |journal=J. Biol. Chem. |volume=270 |issue= 5 |pages= 2274–83 |year= 1995 |pmid= 7836461 |doi=
*cite journal | author=Ou SH, Garcia-Martínez LF, Paulssen EJ, Gaynor RB |title=Role of flanking E box motifs in human immunodeficiency virus type 1 TATA element function. |journal=J. Virol. |volume=68 |issue= 11 |pages= 7188–99 |year= 1994 |pmid= 7933101 |doi=
*cite journal | author=Kashanchi F, Piras G, Radonovich MF, "et al." |title=Direct interaction of human TFIID with the HIV-1 transactivator tat. |journal=Nature |volume=367 |issue= 6460 |pages= 295–9 |year= 1994 |pmid= 8121496 |doi= 10.1038/367295a0
*cite journal | author=Weinzierl RO, Ruppert S, Dynlacht BD, "et al." |title=Cloning and expression of Drosophila TAFII60 and human TAFII70 reveal conserved interactions with other subunits of TFIID. |journal=EMBO J. |volume=12 |issue= 13 |pages= 5303–9 |year= 1994 |pmid= 8262073 |doi=
*cite journal | author=Wang Z, Morris GF, Rice AP, "et al." |title=Wild-type and transactivation-defective mutants of human immunodeficiency virus type 1 Tat protein bind human TATA-binding protein in vitro. |journal=J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. |volume=12 |issue= 2 |pages= 128–38 |year= 1996 |pmid= 8680883 |doi=
*cite journal | author=Pendergrast PS, Morrison D, Tansey WP, Hernandez N |title=Mutations in the carboxy-terminal domain of TBP affect the synthesis of human immunodeficiency virus type 1 full-length and short transcripts similarly. |journal=J. Virol. |volume=70 |issue= 8 |pages= 5025–34 |year= 1996 |pmid= 8764009 |doi=
*cite journal | author=Kashanchi F, Khleif SN, Duvall JF, "et al." |title=Interaction of human immunodeficiency virus type 1 Tat with a unique site of TFIID inhibits negative cofactor Dr1 and stabilizes the TFIID-TFIIA complex. |journal=J. Virol. |volume=70 |issue= 8 |pages= 5503–10 |year= 1996 |pmid= 8764062 |doi=
*cite journal | author=Zhou Q, Sharp PA |title=Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat. |journal=Science |volume=274 |issue= 5287 |pages= 605–10 |year= 1996 |pmid= 8849451 |doi=
*cite journal | author=Tao Y, Guermah M, Martinez E, "et al." |title=Specific interactions and potential functions of human TAFII100. |journal=J. Biol. Chem. |volume=272 |issue= 10 |pages= 6714–21 |year= 1997 |pmid= 9045704 |doi=
*cite journal | author=García-Martínez LF, Ivanov D, Gaynor RB |title=Association of Tat with purified HIV-1 and HIV-2 transcription preinitiation complexes. |journal=J. Biol. Chem. |volume=272 |issue= 11 |pages= 6951–8 |year= 1997 |pmid= 9054383 |doi=
*cite journal | author=Mahanta SK, Scholl T, Yang FC, Strominger JL |title=Transactivation by CIITA, the type II bare lymphocyte syndrome-associated factor, requires participation of multiple regions of the TATA box binding protein. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 12 |pages= 6324–9 |year= 1997 |pmid= 9177216 |doi=
*cite journal | author=Guermah M, Malik S, Roeder RG |title=Involvement of TFIID and USA components in transcriptional activation of the human immunodeficiency virus promoter by NF-kappaB and Sp1. |journal=Mol. Cell. Biol. |volume=18 |issue= 6 |pages= 3234–44 |year= 1998 |pmid= 9584164 |doi=
*cite journal | author=Brand M, Moggs JG, Oulad-Abdelghani M, "et al." |title=UV-damaged DNA-binding protein in the TFTC complex links DNA damage recognition to nucleosome acetylation. |journal=EMBO J. |volume=20 |issue= 12 |pages= 3187–96 |year= 2001 |pmid= 11406595 |doi= 10.1093/emboj/20.12.3187
*cite journal | author=Martinez E, Palhan VB, Tjernberg A, "et al." |title=Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo. |journal=Mol. Cell. Biol. |volume=21 |issue= 20 |pages= 6782–95 |year= 2001 |pmid= 11564863 |doi= 10.1128/MCB.21.20.6782-6795.2001
*cite journal | author=Bell B, Scheer E, Tora L |title=Identification of hTAF(II)80 delta links apoptotic signaling pathways to transcription factor TFIID function. |journal=Mol. Cell |volume=8 |issue= 3 |pages= 591–600 |year= 2001 |pmid= 11583621 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899

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