ATP synthase chain A

Pfam_box
Symbol = ATP-synt_A
Name = ATP synthase A chain


width =
caption =
Pfam= PF00119
InterPro= IPR000568
SMART=
PROSITE = PDOC00420
SCOP = 1c17
TCDB =
OPM family=5
OPM protein=1c17
PDB=PDB3|1ed3C:29-41 PDB3|1c17M:95-266

ATP synthase F0 subunit 6 (or subunit/chain A) (human gene name ATP6) is a subunit of F0 complex of transmembrane F-type ATP synthase.

This subunit is a key component of the proton channel, and may play a direct role in the translocation of protons across the membrane. Catalysis in the F1 complex depends upon the rotation of the central stalk and F0 c-ring, which in turn is driven by the flux of protons through the membrane via the interfacebetween the F0 c-ring and subunit A. The peripheral stalk links subunit A to the external surface of the F1 domain, and is thought to act as a stator to counter the tendency of subunit A and the F1alpha(3)beta(3) catalytic portion to rotate with the central rotary elementcite journal |author=Walker JE, Runswick MJ, Neuhaus D, Montgomery MG, Carbajo RJ, Kellas FA |title=Structure of the F1-binding domain of the stator of bovine F1Fo-ATPase and how it binds an alpha-subunit |journal=J. Mol. Biol. |volume=351 |issue=4 |pages=824–838 |year=2005 |pmid=16045926 |doi=10.1016/j.jmb.2005.06.012] .

3D structure of E.coli homologue of this subunit was modelled based on electron microscopy data (chain M of PDB|1c17). It forms a transmembrane 4-α-bundle.

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Torroni A, Achilli A, Macaulay V, "et al." |title=Harvesting the fruit of the human mtDNA tree. |journal=Trends Genet. |volume=22 |issue= 6 |pages= 339–45 |year= 2006 |pmid= 16678300 |doi= 10.1016/j.tig.2006.04.001
*cite journal | author=Ingman M, Kaessmann H, Pääbo S, Gyllensten U |title=Mitochondrial genome variation and the origin of modern humans. |journal=Nature |volume=408 |issue= 6813 |pages= 708–13 |year= 2001 |pmid= 11130070 |doi= 10.1038/35047064
*cite journal | author=Manfredi G, Fu J, Ojaimi J, "et al." |title=Rescue of a deficiency in ATP synthesis by transfer of MTATP6, a mitochondrial DNA-encoded gene, to the nucleus. |journal=Nat. Genet. |volume=30 |issue= 4 |pages= 394–9 |year= 2002 |pmid= 11925565 |doi= 10.1038/ng851
*cite journal | author=Torigoe T, Izumi H, Ishiguchi H, "et al." |title=Enhanced expression of the human vacuolar H+-ATPase c subunit gene (ATP6L) in response to anticancer agents. |journal=J. Biol. Chem. |volume=277 |issue= 39 |pages= 36534–43 |year= 2002 |pmid= 12133827 |doi= 10.1074/jbc.M202605200
*cite journal | author=Mishmar D, Ruiz-Pesini E, Golik P, "et al." |title=Natural selection shaped regional mtDNA variation in humans. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 1 |pages= 171–6 |year= 2003 |pmid= 12509511 |doi= 10.1073/pnas.0136972100
*cite journal | author=Ingman M, Gyllensten U |title=Mitochondrial genome variation and evolutionary history of Australian and New Guinean aborigines. |journal=Genome Res. |volume=13 |issue= 7 |pages= 1600–6 |year= 2003 |pmid= 12840039 |doi= 10.1101/gr.686603
*cite journal | author=Kong QP, Yao YG, Sun C, "et al." |title=Phylogeny of east Asian mitochondrial DNA lineages inferred from complete sequences. |journal=Am. J. Hum. Genet. |volume=73 |issue= 3 |pages= 671–6 |year= 2003 |pmid= 12870132 |doi= 10.1086/377718
*cite journal | author=Temperley RJ, Seneca SH, Tonska K, "et al." |title=Investigation of a pathogenic mtDNA microdeletion reveals a translation-dependent deadenylation decay pathway in human mitochondria. |journal=Hum. Mol. Genet. |volume=12 |issue= 18 |pages= 2341–8 |year= 2004 |pmid= 12915481 |doi= 10.1093/hmg/ddg238
*cite journal | author=Reuter TY, Medhurst AL, Waisfisz Q, "et al." |title=Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport. |journal=Exp. Cell Res. |volume=289 |issue= 2 |pages= 211–21 |year= 2003 |pmid= 14499622 |doi=
*cite journal | author=Dubot A, Godinot C, Dumur V, "et al." |title=GUG is an efficient initiation codon to translate the human mitochondrial ATP6 gene. |journal=Biochem. Biophys. Res. Commun. |volume=313 |issue= 3 |pages= 687–93 |year= 2004 |pmid= 14697245 |doi=
*cite journal | author=Coble MD, Just RS, O'Callaghan JE, "et al." |title=Single nucleotide polymorphisms over the entire mtDNA genome that increase the power of forensic testing in Caucasians. |journal=Int. J. Legal Med. |volume=118 |issue= 3 |pages= 137–46 |year= 2004 |pmid= 14760490 |doi= 10.1007/s00414-004-0427-6
*cite journal | author=Carrozzo R, Rizza T, Stringaro A, "et al." |title=Maternally-inherited Leigh syndrome-related mutations bolster mitochondrial-mediated apoptosis. |journal=J. Neurochem. |volume=90 |issue= 2 |pages= 490–501 |year= 2004 |pmid= 15228605 |doi= 10.1111/j.1471-4159.2004.02505.x

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