GFRA1

GDNF family receptor alpha 1, also known as GFRA1, is a human gene.

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summary_text = Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for Hirschsprung disease. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.cite web | title = Entrez Gene: GFRA1 GDNF family receptor alpha 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2674| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Treanor JJ, Goodman L, de Sauvage F, "et al." |title=Characterization of a multicomponent receptor for GDNF. |journal=Nature |volume=382 |issue= 6586 |pages= 80–3 |year= 1996 |pmid= 8657309 |doi= 10.1038/382080a0
*cite journal | author=Jing S, Wen D, Yu Y, "et al." |title=GDNF-induced activation of the ret protein tyrosine kinase is mediated by GDNFR-alpha, a novel receptor for GDNF. |journal=Cell |volume=85 |issue= 7 |pages= 1113–24 |year= 1996 |pmid= 8674117 |doi=
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Gattei V, Celetti A, Cerrato A, "et al." |title=Expression of the RET receptor tyrosine kinase and GDNFR-alpha in normal and leukemic human hematopoietic cells and stromal cells of the bone marrow microenvironment. |journal=Blood |volume=89 |issue= 8 |pages= 2925–37 |year= 1997 |pmid= 9108413 |doi=
*cite journal | author=Sanicola M, Hession C, Worley D, "et al." |title=Glial cell line-derived neurotrophic factor-dependent RET activation can be mediated by two different cell-surface accessory proteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 12 |pages= 6238–43 |year= 1997 |pmid= 9177201 |doi=
*cite journal | author=Baloh RH, Tansey MG, Golden JP, "et al." |title=TrnR2, a novel receptor that mediates neurturin and GDNF signaling through Ret. |journal=Neuron |volume=18 |issue= 5 |pages= 793–802 |year= 1997 |pmid= 9182803 |doi=
*cite journal | author=Klein RD, Sherman D, Ho WH, "et al." |title=A GPI-linked protein that interacts with Ret to form a candidate neurturin receptor. |journal=Nature |volume=387 |issue= 6634 |pages= 717–21 |year= 1997 |pmid= 9192898 |doi= 10.1038/42722
*cite journal | author=Jing S, Yu Y, Fang M, "et al." |title=GFRalpha-2 and GFRalpha-3 are two new receptors for ligands of the GDNF family. |journal=J. Biol. Chem. |volume=272 |issue= 52 |pages= 33111–7 |year= 1998 |pmid= 9407096 |doi=
*cite journal | author=Gorodinsky A, Zimonjic DB, Popescu NC, Milbrandt J |title=Assignment of the GDNF family receptor alpha-1 (GFRA1) to human chromosome band 10q26 by in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=78 |issue= 3-4 |pages= 289–90 |year= 1998 |pmid= 9465905 |doi=
*cite journal | author=Eng C, Myers SM, Kogon MD, "et al." |title=Genomic structure and chromosomal localization of the human GDNFR-alpha gene. |journal=Oncogene |volume=16 |issue= 5 |pages= 597–601 |year= 1998 |pmid= 9482105 |doi= 10.1038/sj.onc.1201573
*cite journal | author=Angrist M, Jing S, Bolk S, "et al." |title=Human GFRA1: cloning, mapping, genomic structure, and evaluation as a candidate gene for Hirschsprung disease susceptibility. |journal=Genomics |volume=48 |issue= 3 |pages= 354–62 |year= 1998 |pmid= 9545641 |doi= 10.1006/geno.1997.5191
*cite journal | author=Shefelbine SE, Khorana S, Schultz PN, "et al." |title=Mutational analysis of the GDNF/RET-GDNFR alpha signaling complex in a kindred with vesicoureteral reflux. |journal=Hum. Genet. |volume=102 |issue= 4 |pages= 474–8 |year= 1998 |pmid= 9600247 |doi=
*cite journal | author=Cacalano G, Fariñas I, Wang LC, "et al." |title=GFRalpha1 is an essential receptor component for GDNF in the developing nervous system and kidney. |journal=Neuron |volume=21 |issue= 1 |pages= 53–62 |year= 1998 |pmid= 9697851 |doi=
*cite journal | author=Enokido Y, de Sauvage F, Hongo JA, "et al." |title=GFR alpha-4 and the tyrosine kinase Ret form a functional receptor complex for persephin. |journal=Curr. Biol. |volume=8 |issue= 18 |pages= 1019–22 |year= 1998 |pmid= 9740802 |doi=
*cite journal | author=Tansey MG, Baloh RH, Milbrandt J, Johnson EM |title=GFRalpha-mediated localization of RET to lipid rafts is required for effective downstream signaling, differentiation, and neuronal survival. |journal=Neuron |volume=25 |issue= 3 |pages= 611–23 |year= 2000 |pmid= 10774729 |doi=
*cite journal | author=Hase A, Suzuki H, Arahata K, Akazawa C |title=Expression of human GFR alpha-1 (GDNF receptor) at the neuromuscular junction and myelinated nerves. |journal=Neurosci. Lett. |volume=269 |issue= 1 |pages= 55–7 |year= 2000 |pmid= 10821644 |doi=
*cite journal | author=Cik M, Masure S, Lesage AS, "et al." |title=Binding of GDNF and neurturin to human GDNF family receptor alpha 1 and 2. Influence of cRET and cooperative interactions. |journal=J. Biol. Chem. |volume=275 |issue= 36 |pages= 27505–12 |year= 2000 |pmid= 10829012 |doi= 10.1074/jbc.M000306200
*cite journal | author=Paratcha G, Ledda F, Baars L, "et al." |title=Released GFRalpha1 potentiates downstream signaling, neuronal survival, and differentiation via a novel mechanism of recruitment of c-Ret to lipid rafts. |journal=Neuron |volume=29 |issue= 1 |pages= 171–84 |year= 2001 |pmid= 11182089 |doi=
*cite journal | author=Gimm O, Dziema H, Brown J, "et al." |title=Over-representation of a germline variant in the gene encoding RET co-receptor GFRalpha-1 but not GFRalpha-2 or GFRalpha-3 in cases with sporadic medullary thyroid carcinoma. |journal=Oncogene |volume=20 |issue= 17 |pages= 2161–70 |year= 2001 |pmid= 11360200 |doi= 10.1038/sj.onc.1204289
*cite journal | author=Japón MA, Urbano AG, Sáez C, "et al." |title=Glial-derived neurotropic factor and RET gene expression in normal human anterior pituitary cell types and in pituitary tumors. |journal=J. Clin. Endocrinol. Metab. |volume=87 |issue= 4 |pages= 1879–84 |year= 2002 |pmid= 11932334 |doi=

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