WASF2

WASF2

WAS protein family, member 2, also known as WASF2, is a human gene.

PBB_Summary
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summary_text = This gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function. The published map location (PMID:10381382) has been changed based on recent genomic sequence comparisons, which indicate that the expressed gene is located on chromosome 1, and a pseudogene may be located on chromosome X.cite web | title = Entrez Gene: WASF2 WAS protein family, member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10163| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Jones GE |title=Cellular signaling in macrophage migration and chemotaxis. |journal=J. Leukoc. Biol. |volume=68 |issue= 5 |pages= 593–602 |year= 2000 |pmid= 11073096 |doi=
*cite journal | author=She HY, Rockow S, Tang J, "et al." |title=Wiskott-Aldrich syndrome protein is associated with the adapter protein Grb2 and the epidermal growth factor receptor in living cells. |journal=Mol. Biol. Cell |volume=8 |issue= 9 |pages= 1709–21 |year= 1997 |pmid= 9307968 |doi=
*cite journal | author=Bear JE, Rawls JF, Saxe CL |title=SCAR, a WASP-related protein, isolated as a suppressor of receptor defects in late Dictyostelium development. |journal=J. Cell Biol. |volume=142 |issue= 5 |pages= 1325–35 |year= 1998 |pmid= 9732292 |doi=
*cite journal | author=Wu Y, Dowbenko D, Lasky LA |title=PSTPIP 2, a second tyrosine phosphorylated, cytoskeletal-associated protein that binds a PEST-type protein-tyrosine phosphatase. |journal=J. Biol. Chem. |volume=273 |issue= 46 |pages= 30487–96 |year= 1998 |pmid= 9804817 |doi=
*cite journal | author=Machesky LM, Insall RH |title=Scar1 and the related Wiskott-Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complex. |journal=Curr. Biol. |volume=8 |issue= 25 |pages= 1347–56 |year= 1999 |pmid= 9889097 |doi=
*cite journal | author=Qualmann B, Roos J, DiGregorio PJ, Kelly RB |title=Syndapin I, a synaptic dynamin-binding protein that associates with the neural Wiskott-Aldrich syndrome protein. |journal=Mol. Biol. Cell |volume=10 |issue= 2 |pages= 501–13 |year= 1999 |pmid= 9950691 |doi=
*cite journal | author=Stewart DM, Tian L, Nelson DL |title=Mutations that cause the Wiskott-Aldrich syndrome impair the interaction of Wiskott-Aldrich syndrome protein (WASP) with WASP interacting protein. |journal=J. Immunol. |volume=162 |issue= 8 |pages= 5019–24 |year= 1999 |pmid= 10202051 |doi=
*cite journal | author=Suetsugu S, Miki H, Takenawa T |title=Identification of two human WAVE/SCAR homologues as general actin regulatory molecules which associate with the Arp2/3 complex. |journal=Biochem. Biophys. Res. Commun. |volume=260 |issue= 1 |pages= 296–302 |year= 1999 |pmid= 10381382 |doi= 10.1006/bbrc.1999.0894
*cite journal | author=Morrogh LM, Hinshelwood S, Costello P, "et al." |title=The SH3 domain of Bruton's tyrosine kinase displays altered ligand binding properties when auto-phosphorylated in vitro. |journal=Eur. J. Immunol. |volume=29 |issue= 7 |pages= 2269–79 |year= 1999 |pmid= 10427990 |doi=
*cite journal | author=Banin S, Gout I, Brickell P |title=Interaction between Wiskott-Aldrich Syndrome protein (WASP) and the Fyn protein-tyrosine kinase. |journal=Mol. Biol. Rep. |volume=26 |issue= 3 |pages= 173–7 |year= 1999 |pmid= 10532312 |doi=
*cite journal | author=Westphal RS, Soderling SH, Alto NM, "et al." |title=Scar/WAVE-1, a Wiskott-Aldrich syndrome protein, assembles an actin-associated multi-kinase scaffold. |journal=EMBO J. |volume=19 |issue= 17 |pages= 4589–600 |year= 2000 |pmid= 10970852 |doi= 10.1093/emboj/19.17.4589
*cite journal | author=Miki H, Yamaguchi H, Suetsugu S, Takenawa T |title=IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling. |journal=Nature |volume=408 |issue= 6813 |pages= 732–5 |year= 2001 |pmid= 11130076 |doi= 10.1038/35047107
*cite journal | author=Marchand JB, Kaiser DA, Pollard TD, Higgs HN |title=Interaction of WASP/Scar proteins with actin and vertebrate Arp2/3 complex. |journal=Nat. Cell Biol. |volume=3 |issue= 1 |pages= 76–82 |year= 2001 |pmid= 11146629 |doi= 10.1038/35050590
*cite journal | author=Millard TH, Machesky LM |title=The Wiskott-Aldrich syndrome protein (WASP) family. |journal=Trends Biochem. Sci. |volume=26 |issue= 3 |pages= 198–9 |year= 2001 |pmid= 11246027 |doi=
*cite journal | author=Worby CA, Simonson-Leff N, Clemens JC, "et al." |title=Drosophila Ack targets its substrate, the sorting nexin DSH3PX1, to a protein complex involved in axonal guidance. |journal=J. Biol. Chem. |volume=277 |issue= 11 |pages= 9422–8 |year= 2002 |pmid= 11773052 |doi= 10.1074/jbc.M110172200
*cite journal | author=Miki H, Takenawa T |title=WAVE2 serves a functional partner of IRSp53 by regulating its interaction with Rac. |journal=Biochem. Biophys. Res. Commun. |volume=293 |issue= 1 |pages= 93–9 |year= 2002 |pmid= 12054568 |doi= 10.1016/S0006-291X(02)00218-8
*cite journal | author=Eden S, Rohatgi R, Podtelejnikov AV, "et al." |title=Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck. |journal=Nature |volume=418 |issue= 6899 |pages= 790–3 |year= 2002 |pmid= 12181570 |doi= 10.1038/nature00859
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Innocenti M, Zucconi A, Disanza A, "et al." |title=Abi1 is essential for the formation and activation of a WAVE2 signalling complex. |journal=Nat. Cell Biol. |volume=6 |issue= 4 |pages= 319–27 |year= 2004 |pmid= 15048123 |doi= 10.1038/ncb1105

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