PepT 1

PepT 1 is a solute carrier for oligopeptides. It functions in renal oligopeptide reabsorption.

It is member 1 of solute carrier family 15.

It is encoded by the human gene SLC15A1 [cite web | title = Entrez Gene: SLC15A1 Solute carrier family 15 (oligopeptide transporter), member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6564| accessdate = ]

ee also

* Solute carrier family

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Adibi SA |title=The oligopeptide transporter (Pept-1) in human intestine: biology and function. |journal=Gastroenterology |volume=113 |issue= 1 |pages= 332–40 |year= 1997 |pmid= 9207295 |doi=
*cite journal | author=Adibi SA |title=Regulation of expression of the intestinal oligopeptide transporter (Pept-1) in health and disease. |journal=Am. J. Physiol. Gastrointest. Liver Physiol. |volume=285 |issue= 5 |pages= G779–88 |year= 2003 |pmid= 14561585 |doi= 10.1152/ajpgi.00056.2003
*cite journal | author=Ganapathy ME, Brandsch M, Prasad PD, "et al." |title=Differential recognition of beta -lactam antibiotics by intestinal and renal peptide transporters, PEPT 1 and PEPT 2. |journal=J. Biol. Chem. |volume=270 |issue= 43 |pages= 25672–7 |year= 1995 |pmid= 7592745 |doi=
*cite journal | author=Liang R, Fei YJ, Prasad PD, "et al." |title=Human intestinal H+/peptide cotransporter. Cloning, functional expression, and chromosomal localization. |journal=J. Biol. Chem. |volume=270 |issue= 12 |pages= 6456–63 |year= 1995 |pmid= 7896779 |doi=
*cite journal | author=Thamotharan M, Lombardo YB, Bawani SZ, Adibi SA |title=An active mechanism for completion of the final stage of protein degradation in the liver, lysosomal transport of dipeptides. |journal=J. Biol. Chem. |volume=272 |issue= 18 |pages= 11786–90 |year= 1997 |pmid= 9115234 |doi=
*cite journal | author=Saito H, Motohashi H, Mukai M, Inui K |title=Cloning and characterization of a pH-sensing regulatory factor that modulates transport activity of the human H+/peptide cotransporter, PEPT1. |journal=Biochem. Biophys. Res. Commun. |volume=237 |issue= 3 |pages= 577–82 |year= 1997 |pmid= 9299407 |doi=
*cite journal | author=Gonzalez DE, Covitz KM, Sadée W, Mrsny RJ |title=An oligopeptide transporter is expressed at high levels in the pancreatic carcinoma cell lines AsPc-1 and Capan-2. |journal=Cancer Res. |volume=58 |issue= 3 |pages= 519–25 |year= 1998 |pmid= 9458100 |doi=
*cite journal | author=Walker D, Thwaites DT, Simmons NL, "et al." |title=Substrate upregulation of the human small intestinal peptide transporter, hPepT1. |journal=J. Physiol. (Lond.) |volume=507 ( Pt 3) |issue= |pages= 697–706 |year= 1998 |pmid= 9508831 |doi=
*cite journal | author=Ashida K, Katsura T, Motohashi H, "et al." |title=Thyroid hormone regulates the activity and expression of the peptide transporter PEPT1 in Caco-2 cells. |journal=Am. J. Physiol. Gastrointest. Liver Physiol. |volume=282 |issue= 4 |pages= G617–23 |year= 2002 |pmid= 11897620 |doi= 10.1152/ajpgi.00344.2001
*cite journal | author=Döring F, Martini C, Walter J, Daniel H |title=Importance of a small N-terminal region in mammalian peptide transporters for substrate affinity and function. |journal=J. Membr. Biol. |volume=186 |issue= 2 |pages= 55–62 |year= 2002 |pmid= 11944083 |doi= 10.1007/s00232-001-0135-9
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ford D, Howard A, Hirst BH |title=Expression of the peptide transporter hPepT1 in human colon: a potential route for colonic protein nitrogen and drug absorption. |journal=Histochem. Cell Biol. |volume=119 |issue= 1 |pages= 37–43 |year= 2003 |pmid= 12548404 |doi= 10.1007/s00418-002-0479-y
*cite journal | author=Neumann J, Brandsch M |title=Delta-aminolevulinic acid transport in cancer cells of the human extrahepatic biliary duct. |journal=J. Pharmacol. Exp. Ther. |volume=305 |issue= 1 |pages= 219–24 |year= 2003 |pmid= 12649372 |doi= 10.1124/jpet.102.046573
*cite journal | author=Sun BW, Zhao XC, Wang GJ, "et al." |title=Hormonal regulation of dipeptide transporter (PepT1) in Caco-2 cells with normal and anoxia/reoxygenation management. |journal=World J. Gastroenterol. |volume=9 |issue= 4 |pages= 808–12 |year= 2003 |pmid= 12679938 |doi=
*cite journal | author=Kulkarni AA, Haworth IS, Lee VH |title=Transmembrane segment 5 of the dipeptide transporter hPepT1 forms a part of the substrate translocation pathway. |journal=Biochem. Biophys. Res. Commun. |volume=306 |issue= 1 |pages= 177–85 |year= 2003 |pmid= 12788085 |doi=
*cite journal | author=Kulkarni AA, Haworth IS, Uchiyama T, Lee VH |title=Analysis of transmembrane segment 7 of the dipeptide transporter hPepT1 by cysteine-scanning mutagenesis. |journal=J. Biol. Chem. |volume=278 |issue= 51 |pages= 51833–40 |year= 2004 |pmid= 14532279 |doi= 10.1074/jbc.M308356200
*cite journal | author=Uchiyama T, Kulkarni AA, Davies DL, Lee VH |title=Biophysical evidence for His57 as a proton-binding site in the mammalian intestinal transporter hPepT1. |journal=Pharm. Res. |volume=20 |issue= 12 |pages= 1911–6 |year= 2004 |pmid= 14725353 |doi=
*cite journal | author=Dunham A, Matthews LH, Burton J, "et al." |title=The DNA sequence and analysis of human chromosome 13. |journal=Nature |volume=428 |issue= 6982 |pages= 522–8 |year= 2004 |pmid= 15057823 |doi= 10.1038/nature02379

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