S100A2

S100 calcium binding protein A2, also known as S100A2, is a human gene.

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may have a tumor suppressor function. Chromosomal rearrangements and altered expression of this gene have been implicated in breast cancer.cite web | title = Entrez Gene: S100A2 S100 calcium binding protein A2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6273| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Schäfer BW, Heizmann CW |title=The S100 family of EF-hand calcium-binding proteins: functions and pathology. |journal=Trends Biochem. Sci. |volume=21 |issue= 4 |pages= 134–40 |year= 1996 |pmid= 8701470 |doi=
*cite journal | author=Rasmussen HH, van Damme J, Puype M, "et al." |title=Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes. |journal=Electrophoresis |volume=13 |issue= 12 |pages= 960–9 |year= 1993 |pmid= 1286667 |doi=
*cite journal | author=Lee SW, Tomasetto C, Swisshelm K, "et al." |title=Down-regulation of a member of the S100 gene family in mammary carcinoma cells and reexpression by azadeoxycytidine treatment. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 6 |pages= 2504–8 |year= 1992 |pmid= 1372446 |doi=
*cite journal | author=Schäfer BW, Wicki R, Engelkamp D, "et al." |title=Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein family. |journal=Genomics |volume=25 |issue= 3 |pages= 638–43 |year= 1995 |pmid= 7759097 |doi=
*cite journal | author=Engelkamp D, Schäfer BW, Mattei MG, "et al." |title=Six S100 genes are clustered on human chromosome 1q21: identification of two genes coding for the two previously unreported calcium-binding proteins S100D and S100E. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 14 |pages= 6547–51 |year= 1993 |pmid= 8341667 |doi=
*cite journal | author=Gimona M, Lando Z, Dolginov Y, "et al." |title=Ca2+-dependent interaction of S100A2 with muscle and nonmuscle tropomyosins. |journal=J. Cell. Sci. |volume=110 ( Pt 5) |issue= |pages= 611–21 |year= 1997 |pmid= 9092943 |doi=
*cite journal | author=Böni R, Burg G, Doguoglu A, "et al." |title=Immunohistochemical localization of the Ca2+ binding S100 proteins in normal human skin and melanocytic lesions. |journal=Br. J. Dermatol. |volume=137 |issue= 1 |pages= 39–43 |year= 1997 |pmid= 9274623 |doi=
*cite journal | author=Groves P, Finn BE, Kuźnicki J, Forsén S |title=A model for target protein binding to calcium-activated S100 dimers. |journal=FEBS Lett. |volume=421 |issue= 3 |pages= 175–9 |year= 1998 |pmid= 9468301 |doi=
*cite journal | author=Wicki R, Franz C, Scholl FA, "et al." |title=Repression of the candidate tumor suppressor gene S100A2 in breast cancer is mediated by site-specific hypermethylation. |journal=Cell Calcium |volume=22 |issue= 4 |pages= 243–54 |year= 1998 |pmid= 9481475 |doi=
*cite journal | author=Franz C, Durussel I, Cox JA, "et al." |title=Binding of Ca2+ and Zn2+ to human nuclear S100A2 and mutant proteins. |journal=J. Biol. Chem. |volume=273 |issue= 30 |pages= 18826–34 |year= 1998 |pmid= 9668057 |doi=
*cite journal | author=Mueller A, Bächi T, Höchli M, "et al." |title=Subcellular distribution of S100 proteins in tumor cells and their relocation in response to calcium activation. |journal=Histochem. Cell Biol. |volume=111 |issue= 6 |pages= 453–9 |year= 1999 |pmid= 10429967 |doi=
*cite journal | author=Stradal TB, Troxler H, Heizmann CW, Gimona M |title=Mapping the zinc ligands of S100A2 by site-directed mutagenesis. |journal=J. Biol. Chem. |volume=275 |issue= 18 |pages= 13219–27 |year= 2000 |pmid= 10788426 |doi=
*cite journal | author=Hoyaux D, Decaestecker C, Heizmann CW, "et al." |title=S100 proteins in Corpora amylacea from normal human brain. |journal=Brain Res. |volume=867 |issue= 1-2 |pages= 280–8 |year= 2000 |pmid= 10837826 |doi=
*cite journal | author=Deshpande R, Woods TL, Fu J, "et al." |title=Biochemical characterization of S100A2 in human keratinocytes: subcellular localization, dimerization, and oxidative cross-linking. |journal=J. Invest. Dermatol. |volume=115 |issue= 3 |pages= 477–85 |year= 2000 |pmid= 10951287 |doi= 10.1046/j.1523-1747.2000.00078.x
*cite journal | author=Nagy N, Hoyaux D, Gielen I, "et al." |title=The Ca2+-binding S100A2 protein is differentially expressed in epithelial tissue of glandular or squamous origin. |journal=Histol. Histopathol. |volume=17 |issue= 1 |pages= 123–30 |year= 2002 |pmid= 11813862 |doi=
*cite journal | author=Kyriazanos ID, Tachibana M, Dhar DK, "et al." |title=Expression and prognostic significance of S100A2 protein in squamous cell carcinoma of the esophagus. |journal=Oncol. Rep. |volume=9 |issue= 3 |pages= 503–10 |year= 2002 |pmid= 11956617 |doi=
*cite journal | author=Zhang T, Woods TL, Elder JT |title=Differential responses of S100A2 to oxidative stress and increased intracellular calcium in normal, immortalized, and malignant human keratinocytes. |journal=J. Invest. Dermatol. |volume=119 |issue= 5 |pages= 1196–201 |year= 2003 |pmid= 12445212 |doi= 10.1046/j.1523-1747.2002.19520.x
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Hibi K, Fujitake S, Takase T, "et al." |title=Identification of S100A2 as a target of the DeltaNp63 oncogenic pathway. |journal=Clin. Cancer Res. |volume=9 |issue= 11 |pages= 4282–5 |year= 2004 |pmid= 14519656 |doi=

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes