BNIP3

BCL2/adenovirus E1B 19kDa interacting protein 3, also known as BNIP3, is a human gene.

PBB_Summary
section_title =
summary_text = This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein which is responsible for the protection of virally-induced cell death, as well as E1B 19 kDa-like sequences of BCL2, also an apoptotic protector. This gene contains a BH3 domain and a transmembrane domain, which have been associated with pro-apoptotic function. The dimeric mitochondrial protein encoded by this gene is known to induce apoptosis, even in the presence of BCL2.cite web | title = Entrez Gene: BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=664| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Kataoka N, Ohno M, Moda I, Shimura Y |title=Identification of the factors that interact with NCBP, an 80 kDa nuclear cap binding protein. |journal=Nucleic Acids Res. |volume=23 |issue= 18 |pages= 3638–41 |year= 1995 |pmid= 7478990 |doi=
*cite journal | author=Boyd JM, Malstrom S, Subramanian T, "et al." |title=Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins. |journal=Cell |volume=79 |issue= 2 |pages= 341–51 |year= 1994 |pmid= 7954800 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Chen G, Ray R, Dubik D, "et al." |title=The E1B 19K/Bcl-2-binding protein Nip3 is a dimeric mitochondrial protein that activates apoptosis. |journal=J. Exp. Med. |volume=186 |issue= 12 |pages= 1975–83 |year= 1998 |pmid= 9396766 |doi=
*cite journal | author=Yasuda M, Theodorakis P, Subramanian T, Chinnadurai G |title=Adenovirus E1B-19K/BCL-2 interacting protein BNIP3 contains a BH3 domain and a mitochondrial targeting sequence. |journal=J. Biol. Chem. |volume=273 |issue= 20 |pages= 12415–21 |year= 1998 |pmid= 9575197 |doi=
*cite journal | author=Chen G, Cizeau J, Vande Velde C, "et al." |title=Nix and Nip3 form a subfamily of pro-apoptotic mitochondrial proteins. |journal=J. Biol. Chem. |volume=274 |issue= 1 |pages= 7–10 |year= 1999 |pmid= 9867803 |doi=
*cite journal | author=Yasuda M, Han JW, Dionne CA, "et al." |title=BNIP3alpha: a human homolog of mitochondrial proapoptotic protein BNIP3. |journal=Cancer Res. |volume=59 |issue= 3 |pages= 533–7 |year= 1999 |pmid= 9973195 |doi=
*cite journal | author=Ohi N, Tokunaga A, Tsunoda H, "et al." |title=A novel adenovirus E1B19K-binding protein B5 inhibits apoptosis induced by Nip3 by forming a heterodimer through the C-terminal hydrophobic region. |journal=Cell Death Differ. |volume=6 |issue= 4 |pages= 314–25 |year= 1999 |pmid= 10381623 |doi= 10.1038/sj.cdd.4400493
*cite journal | author=Ray R, Chen G, Vande Velde C, "et al." |title=BNIP3 heterodimerizes with Bcl-2/Bcl-X(L) and induces cell death independent of a Bcl-2 homology 3 (BH3) domain at both mitochondrial and nonmitochondrial sites. |journal=J. Biol. Chem. |volume=275 |issue= 2 |pages= 1439–48 |year= 2000 |pmid= 10625696 |doi=
*cite journal | author=Vande Velde C, Cizeau J, Dubik D, "et al." |title=BNIP3 and genetic control of necrosis-like cell death through the mitochondrial permeability transition pore. |journal=Mol. Cell. Biol. |volume=20 |issue= 15 |pages= 5454–68 |year= 2000 |pmid= 10891486 |doi=
*cite journal | author=Lee SM, Li ML, Tse YC, "et al." |title=Paeoniae Radix, a Chinese herbal extract, inhibit hepatoma cells growth by inducing apoptosis in a p53 independent pathway. |journal=Life Sci. |volume=71 |issue= 19 |pages= 2267–77 |year= 2002 |pmid= 12215374 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Lamy L, Ticchioni M, Rouquette-Jazdanian AK, "et al." |title=CD47 and the 19 kDa interacting protein-3 (BNIP3) in T cell apoptosis. |journal=J. Biol. Chem. |volume=278 |issue= 26 |pages= 23915–21 |year= 2003 |pmid= 12690108 |doi= 10.1074/jbc.M301869200
*cite journal | author=Kothari S, Cizeau J, McMillan-Ward E, "et al." |title=BNIP3 plays a role in hypoxic cell death in human epithelial cells that is inhibited by growth factors EGF and IGF. |journal=Oncogene |volume=22 |issue= 30 |pages= 4734–44 |year= 2003 |pmid= 12879018 |doi= 10.1038/sj.onc.1206666
*cite journal | author=Deloukas P, Earthrowl ME, Grafham DV, "et al." |title=The DNA sequence and comparative analysis of human chromosome 10. |journal=Nature |volume=429 |issue= 6990 |pages= 375–81 |year= 2004 |pmid= 15164054 |doi= 10.1038/nature02462
*cite journal | author=Okami J, Simeone DM, Logsdon CD |title=Silencing of the hypoxia-inducible cell death protein BNIP3 in pancreatic cancer. |journal=Cancer Res. |volume=64 |issue= 15 |pages= 5338–46 |year= 2004 |pmid= 15289340 |doi= 10.1158/0008-5472.CAN-04-0089
*cite journal | author=Giatromanolaki A, Koukourakis MI, Sowter HM, "et al." |title=BNIP3 expression is linked with hypoxia-regulated protein expression and with poor prognosis in non-small cell lung cancer. |journal=Clin. Cancer Res. |volume=10 |issue= 16 |pages= 5566–71 |year= 2005 |pmid= 15328198 |doi= 10.1158/1078-0432.CCR-04-0076
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Shen XY, Zacal N, Singh G, Rainbow AJ |title=Alterations in mitochondrial and apoptosis-regulating gene expression in photodynamic therapy-resistant variants of HT29 colon carcinoma cells. |journal=Photochem. Photobiol. |volume=81 |issue= 2 |pages= 306–13 |year= 2005 |pmid= 15560738 |doi= 10.1562/2004-07-22-RA-242

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