Thymidine kinase 1

Thymidine kinase 1, soluble (gene name TK1), is a human thymidine kinase. [cite web | title = Entrez Gene: Thymidine kinase 1, soluble| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7083| accessdate = ]

Two forms of this protein have been identified in animal cells, one in cytosol and one in mitochondria. Activity of the cytosolic enzyme is high in proliferating cells and peaks during the S-phase of the cell cycle; it is very low in resting cells.

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References

Further reading

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*cite journal | author=Kim YK, Lee AS |title=Identification of a protein-binding site in the promoter of the human thymidine kinase gene required for the G1-S-regulated transcription. |journal=J. Biol. Chem. |volume=267 |issue= 4 |pages= 2723–7 |year= 1992 |pmid= 1370831 |doi=
*cite journal | author=Barik S, Banerjee AK |title=Cloning and expression of the vesicular stomatitis virus phosphoprotein gene in Escherichia coli: analysis of phosphorylation status versus transcriptional activity. |journal=J. Virol. |volume=65 |issue= 4 |pages= 1719–26 |year= 1991 |pmid= 1848304 |doi=
*cite journal | author=Sadava D, Bernard B |title=Transition from cytosolic to mitochondrial thymidine kinase during development in human fetal tissues. |journal=Life Sci. |volume=47 |issue= 25 |pages= 2359–64 |year= 1991 |pmid= 2263164 |doi=
*cite journal | author=Tamiya N, Yusa T, Yamaguchi Y, "et al." |title=Co-purification of thymidylate kinase and cytosolic thymidine kinase from human term placenta by affinity chromatography. |journal=Biochim. Biophys. Acta |volume=995 |issue= 1 |pages= 28–35 |year= 1989 |pmid= 2538159 |doi=
*cite journal | author=Slagel V, Flemington E, Traina-Dorge V, "et al." |title=Clustering and subfamily relationships of the Alu family in the human genome. |journal=Mol. Biol. Evol. |volume=4 |issue= 1 |pages= 19–29 |year= 1988 |pmid= 3128713 |doi=
*cite journal | author=Flemington E, Bradshaw HD, Traina-Dorge V, "et al." |title=Sequence, structure and promoter characterization of the human thymidine kinase gene. |journal=Gene |volume=52 |issue= 2-3 |pages= 267–77 |year= 1987 |pmid= 3301530 |doi=
*cite journal | author=Sherley JL, Kelly TJ |title=Human cytosolic thymidine kinase. Purification and physical characterization of the enzyme from HeLa cells. |journal=J. Biol. Chem. |volume=263 |issue= 1 |pages= 375–82 |year= 1988 |pmid= 3335503 |doi=
*cite journal | author=Kreidberg JA, Kelly TJ |title=Genetic analysis of the human thymidine kinase gene promoter. |journal=Mol. Cell. Biol. |volume=6 |issue= 8 |pages= 2903–9 |year= 1987 |pmid= 3785218 |doi=
*cite journal | author=Bradshaw HD, Deininger PL |title=Human thymidine kinase gene: molecular cloning and nucleotide sequence of a cDNA expressible in mammalian cells. |journal=Mol. Cell. Biol. |volume=4 |issue= 11 |pages= 2316–20 |year= 1985 |pmid= 6549046 |doi=
*cite journal | author=Kuo WL, Hirschhorn R, Huie ML, Hirschhorn K |title=Localization and ordering of acid alpha-glucosidase (GAA) and thymidine kinase (TK1) by fluorescence in situ hybridization. |journal=Hum. Genet. |volume=97 |issue= 3 |pages= 404–6 |year= 1996 |pmid= 8786092 |doi=
*cite journal | author=Chang ZF, Huang DY, Chi LM |title=Serine 13 is the site of mitotic phosphorylation of human thymidine kinase. |journal=J. Biol. Chem. |volume=273 |issue= 20 |pages= 12095–100 |year= 1998 |pmid= 9575153 |doi=
*cite journal | author=Berenstein D, Christensen JF, Kristensen T, "et al." |title=Valine, not methionine, is amino acid 106 in human cytosolic thymidine kinase (TK1). Impact on oligomerization, stability, and kinetic properties. |journal=J. Biol. Chem. |volume=275 |issue= 41 |pages= 32187–92 |year= 2000 |pmid= 10924519 |doi= 10.1074/jbc.M005325200
*cite journal | author=Huang DY, Chang ZF |title=Interaction of human thymidine kinase 1 with p21(Waf1). |journal=Biochem. J. |volume=356 |issue= Pt 3 |pages= 829–34 |year= 2001 |pmid= 11389691 |doi=
*cite journal | author=Fujiwaki R, Hata K, Moriyama M, "et al." |title=Clinical value of thymidine kinase in patients with cervical carcinoma. |journal=Oncology |volume=61 |issue= 1 |pages= 47–54 |year= 2001 |pmid= 11474248 |doi=
*cite journal | author=Fujiwaki R, Hata K, Nakayama K, "et al." |title=Thymidine kinase in epithelial ovarian cancer: relationship with the other pyrimidine pathway enzymes. |journal=Int. J. Cancer |volume=99 |issue= 3 |pages= 328–35 |year= 2002 |pmid= 11992400 |doi= 10.1002/ijc.10319
*cite journal | author=Mao Y, Wu J, Wang N, "et al." |title=A comparative study: immunohistochemical detection of cytosolic thymidine kinase and proliferating cell nuclear antigen in breast cancer. |journal=Cancer Invest. |volume=20 |issue= 7-8 |pages= 922–31 |year= 2002 |pmid= 12449723 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Gilles SI, Romain S, Casellas P, "et al." |title=Mutation analysis in the coding sequence of thymidine kinase 1 in breast and colorectal cancer. |journal=Int. J. Biol. Markers |volume=18 |issue= 1 |pages= 1–6 |year= 2003 |pmid= 12699056 |doi=
*cite journal | author=Han T, Fernandez M, Sarkar M, Agarwal RP |title=2', 3'-Dideoxycytidine represses thymidine kinases 1 and 2 expression in T-lymphoid cells. |journal=Life Sci. |volume=74 |issue= 7 |pages= 835–42 |year= 2004 |pmid= 14659972 |doi=
*cite journal | author=Li CL, Lu CY, Ke PY, Chang ZF |title=Perturbation of ATP-induced tetramerization of human cytosolic thymidine kinase by substitution of serine-13 with aspartic acid at the mitotic phosphorylation site. |journal=Biochem. Biophys. Res. Commun. |volume=313 |issue= 3 |pages= 587–93 |year= 2004 |pmid= 14697231 |doi=

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