RHEB

Ras homolog enriched in brain, also known as RHEB, is a human gene.

PBB_Summary
section_title =
summary_text = This gene is a member of the small GTPase superfamily and encodes a lipid-anchored, cell membrane protein with five repeats of the RAS-related GTP-binding region. This protein is vital in regulation of growth and cell cycle progression due to its role in the insulin/TOR/S6K signaling pathway. The protein has GTPase activity and shuttles between a GDP-bound form and a GTP-bound form, and farnesylation of the protein is required for this activity. Three pseudogenes have been mapped, two on chromosome 10 and one on chromosome 22.cite web | title = Entrez Gene: RHEB Ras homolog enriched in brain| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6009| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Yamagata K, Sanders LK, Kaufmann WE, "et al." |title=rheb, a growth factor- and synaptic activity-regulated gene, encodes a novel Ras-related protein. |journal=J. Biol. Chem. |volume=269 |issue= 23 |pages= 16333–9 |year= 1994 |pmid= 8206940 |doi=
*cite journal | author=Gromov PS, Madsen P, Tomerup N, Celis JE |title=A novel approach for expression cloning of small GTPases: identification, tissue distribution and chromosome mapping of the human homolog of rheb. |journal=FEBS Lett. |volume=377 |issue= 2 |pages= 221–6 |year= 1996 |pmid= 8543055 |doi=
*cite journal | author=Mizuki N, Kimura M, Ohno S, "et al." |title=Isolation of cDNA and genomic clones of a human Ras-related GTP-binding protein gene and its chromosomal localization to the long arm of chromosome 7, 7q36. |journal=Genomics |volume=34 |issue= 1 |pages= 114–8 |year= 1996 |pmid= 8661031 |doi=
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Yee WM, Worley PF |title=Rheb interacts with Raf-1 kinase and may function to integrate growth factor- and protein kinase A-dependent signals. |journal=Mol. Cell. Biol. |volume=17 |issue= 2 |pages= 921–33 |year= 1997 |pmid= 9001246 |doi=
*cite journal | author=Clark GJ, Kinch MS, Rogers-Graham K, "et al." |title=The Ras-related protein Rheb is farnesylated and antagonizes Ras signaling and transformation. |journal=J. Biol. Chem. |volume=272 |issue= 16 |pages= 10608–15 |year= 1997 |pmid= 9099708 |doi=
*cite journal | author=Inohara N, Ding L, Chen S, Núñez G |title=harakiri, a novel regulator of cell death, encodes a protein that activates apoptosis and interacts selectively with survival-promoting proteins Bcl-2 and Bcl-X(L). |journal=EMBO J. |volume=16 |issue= 7 |pages= 1686–94 |year= 1997 |pmid= 9130713 |doi= 10.1093/emboj/16.7.1686
*cite journal | author= |title=Toward a complete human genome sequence. |journal=Genome Res. |volume=8 |issue= 11 |pages= 1097–108 |year= 1999 |pmid= 9847074 |doi=
*cite journal | author=Kita K, Wu YP, Sugaya S, "et al." |title=Search for UV-responsive genes in human cells by differential mRNA display: involvement of human ras-related GTP-binding protein, Rheb, in UV susceptibility. |journal=Biochem. Biophys. Res. Commun. |volume=274 |issue= 3 |pages= 859–64 |year= 2000 |pmid= 10924367 |doi= 10.1006/bbrc.2000.3220
*cite journal | author=Hanzal-Bayer M, Renault L, Roversi P, "et al." |title=The complex of Arl2-GTP and PDE delta: from structure to function. |journal=EMBO J. |volume=21 |issue= 9 |pages= 2095–106 |year= 2002 |pmid= 11980706 |doi= 10.1093/emboj/21.9.2095
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Scherer SW, Cheung J, MacDonald JR, "et al." |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767–72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423
*cite journal | author=Zhang Y, Gao X, Saucedo LJ, "et al." |title=Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins. |journal=Nat. Cell Biol. |volume=5 |issue= 6 |pages= 578–81 |year= 2003 |pmid= 12771962 |doi= 10.1038/ncb999
*cite journal | author=Garami A, Zwartkruis FJ, Nobukuni T, "et al." |title=Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2. |journal=Mol. Cell |volume=11 |issue= 6 |pages= 1457–66 |year= 2003 |pmid= 12820960 |doi=
*cite journal | author=Castro AF, Rebhun JF, Clark GJ, Quilliam LA |title=Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycin- and farnesylation-dependent manner. |journal=J. Biol. Chem. |volume=278 |issue= 35 |pages= 32493–6 |year= 2003 |pmid= 12842888 |doi= 10.1074/jbc.C300226200
*cite journal | author=Hillier LW, Fulton RS, Fulton LA, "et al." |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157–64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782
*cite journal | author=Tabancay AP, Gau CL, Machado IM, "et al." |title=Identification of dominant negative mutants of Rheb GTPase and their use to implicate the involvement of human Rheb in the activation of p70S6K. |journal=J. Biol. Chem. |volume=278 |issue= 41 |pages= 39921–30 |year= 2003 |pmid= 12869548 |doi= 10.1074/jbc.M306553200
*cite journal | author=Inoki K, Li Y, Xu T, Guan KL |title=Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling. |journal=Genes Dev. |volume=17 |issue= 15 |pages= 1829–34 |year= 2003 |pmid= 12869586 |doi= 10.1101/gad.1110003
*cite journal | author=Tee AR, Manning BD, Roux PP, "et al." |title=Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb. |journal=Curr. Biol. |volume=13 |issue= 15 |pages= 1259–68 |year= 2004 |pmid= 12906785 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285

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