T-cell lymphoma invasion and metastasis-inducing protein 1

T-cell lymphoma invasion and metastasis-inducing protein 1

T-cell lymphoma invasion and metastasis-inducing protein 1, also known as TIAM1, is a human protein gene. [cite web | title = Entrez Gene: TIAM1 T-cell lymphoma invasion and metastasis 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7074| accessdate = ]

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It modulates the activity of Rho GTP-binding proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of Rho-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA. It is tightly associate with BAIAP2 as a subunit.

It was found in virtually all analyzed tumor cell lines including B- and T-lymphomas, neuroblastomas, melanomas and carcinomas. It contains one DH (DBL-homology) domain, one PDZ domain, two PH domains and one Ras-binding RBD domain.


Further reading

citations =
*cite journal | author=Habets GG, van der Kammen RA, Stam JC, "et al." |title=Sequence of the human invasion-inducing TIAM1 gene, its conservation in evolution and its expression in tumor cell lines of different tissue origin. |journal=Oncogene |volume=10 |issue= 7 |pages= 1371–6 |year= 1995 |pmid= 7731688 |doi=
*cite journal | author=Habets GG, van der Kammen RA, Jenkins NA, "et al." |title=The invasion-inducing TIAM1 gene maps to human chromosome band 21q22 and mouse chromosome 16. |journal=Cytogenet. Cell Genet. |volume=70 |issue= 1-2 |pages= 48–51 |year= 1995 |pmid= 7736788 |doi=
*cite journal | author=Michiels F, Habets GG, Stam JC, "et al." |title=A role for Rac in Tiam1-induced membrane ruffling and invasion. |journal=Nature |volume=375 |issue= 6529 |pages= 338–40 |year= 1995 |pmid= 7753201 |doi= 10.1038/375338a0
*cite journal | author=Chen H, Antonarakis SE |title=Localization of a human homolog of the mouse Tiam-1 gene to chromosome 21q22.1. |journal=Genomics |volume=30 |issue= 1 |pages= 123–7 |year= 1996 |pmid= 8595894 |doi= 10.1006/geno.1995.0025
*cite journal | author=Andersson B, Wentland MA, Ricafrente JY, "et al." |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138
*cite journal | author=Michiels F, Stam JC, Hordijk PL, "et al." |title=Regulated membrane localization of Tiam1, mediated by the NH2-terminal pleckstrin homology domain, is required for Rac-dependent membrane ruffling and C-Jun NH2-terminal kinase activation. |journal=J. Cell Biol. |volume=137 |issue= 2 |pages= 387–98 |year= 1997 |pmid= 9128250 |doi=
*cite journal | author=Fleming IN, Elliott CM, Buchanan FG, "et al." |title=Ca2+/calmodulin-dependent protein kinase II regulates Tiam1 by reversible protein phosphorylation. |journal=J. Biol. Chem. |volume=274 |issue= 18 |pages= 12753–8 |year= 1999 |pmid= 10212259 |doi=
*cite journal | author=Bourguignon LY, Zhu H, Shao L, Chen YW |title=CD44 interaction with tiam1 promotes Rac1 signaling and hyaluronic acid-mediated breast tumor cell migration. |journal=J. Biol. Chem. |volume=275 |issue= 3 |pages= 1829–38 |year= 2000 |pmid= 10636882 |doi=
*cite journal | author=Hattori M, Fujiyama A, Taylor TD, "et al." |title=The DNA sequence of human chromosome 21. |journal=Nature |volume=405 |issue= 6784 |pages= 311–9 |year= 2000 |pmid= 10830953 |doi= 10.1038/35012518
*cite journal | author=Crompton AM, Foley LH, Wood A, "et al." |title=Regulation of Tiam1 nucleotide exchange activity by pleckstrin domain binding ligands. |journal=J. Biol. Chem. |volume=275 |issue= 33 |pages= 25751–9 |year= 2000 |pmid= 10835422 |doi= 10.1074/jbc.M002050200
*cite journal | author=Bourguignon LY, Zhu H, Shao L, Chen YW |title=Ankyrin-Tiam1 interaction promotes Rac1 signaling and metastatic breast tumor cell invasion and migration. |journal=J. Cell Biol. |volume=150 |issue= 1 |pages= 177–91 |year= 2000 |pmid= 10893266 |doi=
*cite journal | author=Worthylake DK, Rossman KL, Sondek J |title=Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1. |journal=Nature |volume=408 |issue= 6813 |pages= 682–8 |year= 2001 |pmid= 11130063 |doi= 10.1038/35047014
*cite journal | author=Otsuki Y, Tanaka M, Yoshii S, "et al." |title=Tumor metastasis suppressor nm23H1 regulates Rac1 GTPase by interaction with Tiam1. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 8 |pages= 4385–90 |year= 2001 |pmid= 11274357 |doi= 10.1073/pnas.071411598
*cite journal | author=Gao Y, Xing J, Streuli M, "et al." |title=Trp(56) of rac1 specifies interaction with a subset of guanine nucleotide exchange factors. |journal=J. Biol. Chem. |volume=276 |issue= 50 |pages= 47530–41 |year= 2002 |pmid= 11595749 |doi= 10.1074/jbc.M108865200
*cite journal | author=Buchsbaum RJ, Connolly BA, Feig LA |title=Interaction of Rac exchange factors Tiam1 and Ras-GRF1 with a scaffold for the p38 mitogen-activated protein kinase cascade. |journal=Mol. Cell. Biol. |volume=22 |issue= 12 |pages= 4073–85 |year= 2002 |pmid= 12024021 |doi=
*cite journal | author=Lambert JM, Lambert QT, Reuther GW, "et al." |title=Tiam1 mediates Ras activation of Rac by a PI(3)K-independent mechanism. |journal=Nat. Cell Biol. |volume=4 |issue= 8 |pages= 621–5 |year= 2002 |pmid= 12134164 |doi= 10.1038/ncb833
*cite journal | author=Wennerberg K, Ellerbroek SM, Liu RY, "et al." |title=RhoG signals in parallel with Rac1 and Cdc42. |journal=J. Biol. Chem. |volume=277 |issue= 49 |pages= 47810–7 |year= 2003 |pmid= 12376551 |doi= 10.1074/jbc.M203816200
*cite journal | author=Otsuki Y, Tanaka M, Kamo T, "et al." |title=Guanine nucleotide exchange factor, Tiam1, directly binds to c-Myc and interferes with c-Myc-mediated apoptosis in rat-1 fibroblasts. |journal=J. Biol. Chem. |volume=278 |issue= 7 |pages= 5132–40 |year= 2003 |pmid= 12446731 |doi= 10.1074/jbc.M206733200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Buchsbaum RJ, Connolly BA, Feig LA |title=Regulation of p70 S6 kinase by complex formation between the Rac guanine nucleotide exchange factor (Rac-GEF) Tiam1 and the scaffold spinophilin. |journal=J. Biol. Chem. |volume=278 |issue= 21 |pages= 18833–41 |year= 2003 |pmid= 12531897 |doi= 10.1074/jbc.M207876200

External links

* - Calculated spatial position of TIAM1-RAC2 complex in membrane

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