SNAP23

Synaptosomal-associated protein, 23kDa, also known as SNAP23, is a human gene.

PBB_Summary
section_title =
summary_text = Specificity of vesicular transport is regulated, in part, by the interaction of a vesicle-associated membrane protein termed synaptobrevin/VAMP with a target compartment membrane protein termed syntaxin. These proteins, together with SNAP25 (synaptosome-associated protein of 25 kDa), form a complex which serves as a binding site for the general membrane fusion machinery. Synaptobrevin/VAMP and syntaxin are believed to be involved in vesicular transport in most, if not all cells, while SNAP25 is present almost exclusively in the brain, suggesting that a ubiquitously expressed homolog of SNAP25 exists to facilitate transport vesicle/target membrane fusion in other tissues. The protein encoded by this gene is structurally and functionally similar to SNAP25 and binds tightly to multiple syntaxins and synaptobrevins/VAMPs. It is an essential component of the high affinity receptor for the general membrane fusion machinery and is an important regulator of transport vesicle docking and fusion. Two alternative transcript variants encoding different protein isoforms have been described for this gene.cite web | title = Entrez Gene: SNAP23 synaptosomal-associated protein, 23kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8773| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Ravichandran V, Chawla A, Roche PA |title=Identification of a novel syntaxin- and synaptobrevin/VAMP-binding protein, SNAP-23, expressed in non-neuronal tissues. |journal=J. Biol. Chem. |volume=271 |issue= 23 |pages= 13300–3 |year= 1996 |pmid= 8663154 |doi=
*cite journal | author=Mollinedo F, Lazo PA |title=Identification of two isoforms of the vesicle-membrane fusion protein SNAP-23 in human neutrophils and HL-60 cells. |journal=Biochem. Biophys. Res. Commun. |volume=231 |issue= 3 |pages= 808–12 |year= 1997 |pmid= 9070898 |doi= 10.1006/bbrc.1997.6196
*cite journal | author=Araki S, Tamori Y, Kawanishi M, "et al." |title=Inhibition of the binding of SNAP-23 to syntaxin 4 by Munc18c. |journal=Biochem. Biophys. Res. Commun. |volume=234 |issue= 1 |pages= 257–62 |year= 1997 |pmid= 9168999 |doi= 10.1006/bbrc.1997.6560
*cite journal | author=Tang BL, Tan AE, Lim LK, "et al." |title=Syntaxin 12, a member of the syntaxin family localized to the endosome. |journal=J. Biol. Chem. |volume=273 |issue= 12 |pages= 6944–50 |year= 1998 |pmid= 9507000 |doi=
*cite journal | author=Galli T, Zahraoui A, Vaidyanathan VV, "et al." |title=A novel tetanus neurotoxin-insensitive vesicle-associated membrane protein in SNARE complexes of the apical plasma membrane of epithelial cells. |journal=Mol. Biol. Cell |volume=9 |issue= 6 |pages= 1437–48 |year= 1998 |pmid= 9614185 |doi=
*cite journal | author=Foster LJ, Yeung B, Mohtashami M, "et al." |title=Binary interactions of the SNARE proteins syntaxin-4, SNAP23, and VAMP-2 and their regulation by phosphorylation. |journal=Biochemistry |volume=37 |issue= 31 |pages= 11089–96 |year= 1998 |pmid= 9693005 |doi= 10.1021/bi980253t
*cite journal | author=Riento K, Galli T, Jansson S, "et al." |title=Interaction of Munc-18-2 with syntaxin 3 controls the association of apical SNAREs in epithelial cells. |journal=J. Cell. Sci. |volume=111 ( Pt 17) |issue= |pages= 2681–8 |year= 1999 |pmid= 9701566 |doi=
*cite journal | author=Guo Z, Turner C, Castle D |title=Relocation of the t-SNARE SNAP-23 from lamellipodia-like cell surface projections regulates compound exocytosis in mast cells. |journal=Cell |volume=94 |issue= 4 |pages= 537–48 |year= 1998 |pmid= 9727496 |doi=
*cite journal | author=Inoue T, Nielsen S, Mandon B, "et al." |title=SNAP-23 in rat kidney: colocalization with aquaporin-2 in collecting duct vesicles. |journal=Am. J. Physiol. |volume=275 |issue= 5 Pt 2 |pages= F752–60 |year= 1998 |pmid= 9815132 |doi=
*cite journal | author=Valdez AC, Cabaniols JP, Brown MJ, Roche PA |title=Syntaxin 11 is associated with SNAP-23 on late endosomes and the trans-Golgi network. |journal=J. Cell. Sci. |volume=112 ( Pt 6) |issue= |pages= 845–54 |year= 1999 |pmid= 10036234 |doi=
*cite journal | author=Okamoto M, Schoch S, Südhof TC |title=EHSH1/intersectin, a protein that contains EH and SH3 domains and binds to dynamin and SNAP-25. A protein connection between exocytosis and endocytosis? |journal=J. Biol. Chem. |volume=274 |issue= 26 |pages= 18446–54 |year= 1999 |pmid= 10373452 |doi=
*cite journal | author=Cabaniols JP, Ravichandran V, Roche PA |title=Phosphorylation of SNAP-23 by the novel kinase SNAK regulates t-SNARE complex assembly. |journal=Mol. Biol. Cell |volume=10 |issue= 12 |pages= 4033–41 |year= 2000 |pmid= 10588641 |doi=
*cite journal | author=Kawanishi M, Tamori Y, Okazawa H, "et al." |title=Role of SNAP23 in insulin-induced translocation of GLUT4 in 3T3-L1 adipocytes. Mediation of complex formation between syntaxin4 and VAMP2. |journal=J. Biol. Chem. |volume=275 |issue= 11 |pages= 8240–7 |year= 2000 |pmid= 10713150 |doi=
*cite journal | author=Paumet F, Le Mao J, Martin S, "et al." |title=Soluble NSF attachment protein receptors (SNAREs) in RBL-2H3 mast cells: functional role of syntaxin 4 in exocytosis and identification of a vesicle-associated membrane protein 8-containing secretory compartment. |journal=J. Immunol. |volume=164 |issue= 11 |pages= 5850–7 |year= 2000 |pmid= 10820264 |doi=
*cite journal | author=Scales SJ, Chen YA, Yoo BY, "et al." |title=SNAREs contribute to the specificity of membrane fusion. |journal=Neuron |volume=26 |issue= 2 |pages= 457–64 |year= 2000 |pmid= 10839363 |doi=
*cite journal | author=Martín-Martín B, Nabokina SM, Blasi J, "et al." |title=Involvement of SNAP-23 and syntaxin 6 in human neutrophil exocytosis. |journal=Blood |volume=96 |issue= 7 |pages= 2574–83 |year= 2000 |pmid= 11001914 |doi=
*cite journal | author=Faigle W, Colucci-Guyon E, Louvard D, "et al." |title=Vimentin filaments in fibroblasts are a reservoir for SNAP23, a component of the membrane fusion machinery. |journal=Mol. Biol. Cell |volume=11 |issue= 10 |pages= 3485–94 |year= 2000 |pmid= 11029050 |doi=
*cite journal | author=Lazo PA, Nadal M, Ferrer M, "et al." |title=Genomic organization, chromosomal localization, alternative splicing, and isoforms of the human synaptosome-associated protein-23 gene implicated in vesicle-membrane fusion processes. |journal=Hum. Genet. |volume=108 |issue= 3 |pages= 211–5 |year= 2001 |pmid= 11354632 |doi=
*cite journal | author=Shukla A, Corydon TJ, Nielsen S, "et al." |title=Identification of three new splice variants of the SNARE protein SNAP-23. |journal=Biochem. Biophys. Res. Commun. |volume=285 |issue= 2 |pages= 320–7 |year= 2001 |pmid= 11444845 |doi= 10.1006/bbrc.2001.5144
*cite journal | author=Logan MR, Lacy P, Bablitz B, Moqbel R |title=Expression of eosinophil target SNAREs as potential cognate receptors for vesicle-associated membrane protein-2 in exocytosis. |journal=J. Allergy Clin. Immunol. |volume=109 |issue= 2 |pages= 299–306 |year= 2002 |pmid= 11842301 |doi=

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes