- PINK1
PTEN induced putative kinase 1, also known as PINK1, is a human
gene .PBB_Summary
section_title =
summary_text = This gene encodes a serine/threonine protein kinase that localizes to mitochondria. It is thought to protect cells from stress-induced mitochondrial dysfunction. Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease.cite web | title = Entrez Gene: PINK1 PTEN induced putative kinase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=65018| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Heutink P |title=PINK-1 and DJ-1--new genes for autosomal recessive Parkinson's disease. |journal=J. Neural Transm. Suppl. |volume= |issue= 70 |pages= 215–9 |year= 2006 |pmid= 17017532 |doi=
*cite journal | author=Valente EM, Bentivoglio AR, Dixon PH, "et al." |title=Localization of a novel locus for autosomal recessive early-onset parkinsonism, PARK6, on human chromosome 1p35-p36. |journal=Am. J. Hum. Genet. |volume=68 |issue= 4 |pages= 895–900 |year= 2001 |pmid= 11254447 |doi=
*cite journal | author=Unoki M, Nakamura Y |title=Growth-suppressive effects of BPOZ and EGR2, two genes involved in the PTEN signaling pathway. |journal=Oncogene |volume=20 |issue= 33 |pages= 4457–65 |year= 2001 |pmid= 11494141 |doi= 10.1038/sj.onc.1204608
*cite journal | author=Khan NL, Valente EM, Bentivoglio AR, "et al." |title=Clinical and subclinical dopaminergic dysfunction in PARK6-linked parkinsonism: an 18F-dopa PET study. |journal=Ann. Neurol. |volume=52 |issue= 6 |pages= 849–53 |year= 2002 |pmid= 12447943 |doi= 10.1002/ana.10417
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Bonifati V, Dekker MC, Vanacore N, "et al." |title=Autosomal recessive early onset parkinsonism is linked to three loci: PARK2, PARK6, and PARK7. |journal=Neurol. Sci. |volume=23 Suppl 2 |issue= |pages= S59–60 |year= 2003 |pmid= 12548343 |doi= 10.1007/s100720200069
*cite journal | author=Valente EM, Brancati F, Caputo V, "et al." |title=PARK6 is a common cause of familial parkinsonism. |journal=Neurol. Sci. |volume=23 Suppl 2 |issue= |pages= S117–8 |year= 2003 |pmid= 12548371 |doi= 10.1007/s100720200097
*cite journal | author=Nakajima A, Kataoka K, Hong M, "et al." |title=BRPK, a novel protein kinase showing increased expression in mouse cancer cell lines with higher metastatic potential. |journal=Cancer Lett. |volume=201 |issue= 2 |pages= 195–201 |year= 2004 |pmid= 14607334 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Valente EM, Abou-Sleiman PM, Caputo V, "et al." |title=Hereditary early-onset Parkinson's disease caused by mutations in PINK1. |journal=Science |volume=304 |issue= 5674 |pages= 1158–60 |year= 2004 |pmid= 15087508 |doi= 10.1126/science.1096284
*cite journal | author=Healy DG, Abou-Sleiman PM, Ahmadi KR, "et al." |title=The gene responsible for PARK6 Parkinson's disease, PINK1, does not influence common forms of parkinsonism. |journal=Ann. Neurol. |volume=56 |issue= 3 |pages= 329–35 |year= 2004 |pmid= 15349859 |doi= 10.1002/ana.20206
*cite journal | author=Valente EM, Salvi S, Ialongo T, "et al." |title=PINK1 mutations are associated with sporadic early-onset parkinsonism. |journal=Ann. Neurol. |volume=56 |issue= 3 |pages= 336–41 |year= 2004 |pmid= 15349860 |doi= 10.1002/ana.20256
*cite journal | author=Hatano Y, Li Y, Sato K, "et al." |title=Novel PINK1 mutations in early-onset parkinsonism. |journal=Ann. Neurol. |volume=56 |issue= 3 |pages= 424–7 |year= 2004 |pmid= 15349870 |doi= 10.1002/ana.20251
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Hatano Y, Sato K, Elibol B, "et al." |title=PARK6-linked autosomal recessive early-onset parkinsonism in Asian populations. |journal=Neurology |volume=63 |issue= 8 |pages= 1482–5 |year= 2006 |pmid= 15505170 |doi=
*cite journal | author=Healy DG, Abou-Sleiman PM, Gibson JM, "et al." |title=PINK1 (PARK6) associated Parkinson disease in Ireland. |journal=Neurology |volume=63 |issue= 8 |pages= 1486–8 |year= 2006 |pmid= 15505171 |doi=
*cite journal | author=Rogaeva E, Johnson J, Lang AE, "et al." |title=Analysis of the PINK1 gene in a large cohort of cases with Parkinson disease. |journal=Arch. Neurol. |volume=61 |issue= 12 |pages= 1898–904 |year= 2005 |pmid= 15596610 |doi= 10.1001/archneur.61.12.1898
*cite journal | author=Beilina A, Van Der Brug M, Ahmad R, "et al." |title=Mutations in PTEN-induced putative kinase 1 associated with recessive parkinsonism have differential effects on protein stability. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue= 16 |pages= 5703–8 |year= 2005 |pmid= 15824318 |doi= 10.1073/pnas.0500617102
*cite journal | author=Deng H, Le WD, Zhang X, "et al." |title=G309D and W437OPA PINK1 mutations in Caucasian Parkinson's disease patients. |journal=Acta Neurol. Scand. |volume=111 |issue= 6 |pages= 351–2 |year= 2005 |pmid= 15876334 |doi= 10.1111/j.1600-0404.2005.00383.x
*cite journal | author=Li Y, Tomiyama H, Sato K, "et al." |title=Clinicogenetic study of PINK1 mutations in autosomal recessive early-onset parkinsonism. |journal=Neurology |volume=64 |issue= 11 |pages= 1955–7 |year= 2005 |pmid= 15955953 |doi= 10.1212/01.WNL.0000164009.36740.4EPBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes
Wikimedia Foundation. 2010.