KPNA5

Karyopherin alpha 5 (importin alpha 6), also known as KPNA5, is a human gene.

PBB_Summary
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summary_text = The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC) which consists of 60-100 proteins and is probably 120 million daltons in molecular size. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion; larger molecules are transported by an active process. Most nuclear proteins contain short basic amino acid sequences known as nuclear localization signals (NLSs). KPNA5 protein belongs to the importin alpha protein family and is thought to be involved in NLS-dependent protein import into the nucleuscite web | title = Entrez Gene: KPNA5 karyopherin alpha 5 (importin alpha 6)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3841| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Bukrinsky MI, Haffar OK |title=HIV-1 nuclear import: in search of a leader. |journal=Front. Biosci. |volume=2 |issue= |pages= d578–87 |year= 2004 |pmid= 9366553 |doi=
*cite journal | author=Bukrinsky MI, Haffar OK |title=HIV-1 nuclear import: matrix protein is back on center stage, this time together with Vpr. |journal=Mol. Med. |volume=4 |issue= 3 |pages= 138–43 |year= 1998 |pmid= 9562972 |doi=
*cite journal | author=Bukrinsky MI, Sharova N, Dempsey MP, "et al." |title=Active nuclear import of human immunodeficiency virus type 1 preintegration complexes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 14 |pages= 6580–4 |year= 1992 |pmid= 1631159 |doi=
*cite journal | author=Sharova N, Bukrinskaya A |title=p17 and p17-containing gag precursors of input human immunodeficiency virus are transported into the nuclei of infected cells. |journal=AIDS Res. Hum. Retroviruses |volume=7 |issue= 3 |pages= 303–6 |year= 1991 |pmid= 2064827 |doi=
*cite journal | author=Di Marzio P, Choe S, Ebright M, "et al." |title=Mutational analysis of cell cycle arrest, nuclear localization and virion packaging of human immunodeficiency virus type 1 Vpr. |journal=J. Virol. |volume=69 |issue= 12 |pages= 7909–16 |year= 1996 |pmid= 7494303 |doi=
*cite journal | author=Adams MD, Kerlavage AR, Fleischmann RD, "et al." |title=Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence. |journal=Nature |volume=377 |issue= 6547 Suppl |pages= 3–174 |year= 1995 |pmid= 7566098 |doi=
*cite journal | author=Gallay P, Swingler S, Song J, "et al." |title=HIV nuclear import is governed by the phosphotyrosine-mediated binding of matrix to the core domain of integrase. |journal=Cell |volume=83 |issue= 4 |pages= 569–76 |year= 1995 |pmid= 7585960 |doi=
*cite journal | author=Freed EO, Englund G, Martin MA |title=Role of the basic domain of human immunodeficiency virus type 1 matrix in macrophage infection. |journal=J. Virol. |volume=69 |issue= 6 |pages= 3949–54 |year= 1995 |pmid= 7745752 |doi=
*cite journal | author=Gallay P, Swingler S, Aiken C, Trono D |title=HIV-1 infection of nondividing cells: C-terminal tyrosine phosphorylation of the viral matrix protein is a key regulator. |journal=Cell |volume=80 |issue= 3 |pages= 379–88 |year= 1995 |pmid= 7859280 |doi=
*cite journal | author=von Schwedler U, Kornbluth RS, Trono D |title=The nuclear localization signal of the matrix protein of human immunodeficiency virus type 1 allows the establishment of infection in macrophages and quiescent T lymphocytes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 15 |pages= 6992–6 |year= 1994 |pmid= 8041734 |doi=
*cite journal | author=Heinzinger NK, Bukinsky MI, Haggerty SA, "et al." |title=The Vpr protein of human immunodeficiency virus type 1 influences nuclear localization of viral nucleic acids in nondividing host cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 15 |pages= 7311–5 |year= 1994 |pmid= 8041786 |doi=
*cite journal | author=Bukrinsky MI, Haggerty S, Dempsey MP, "et al." |title=A nuclear localization signal within HIV-1 matrix protein that governs infection of non-dividing cells. |journal=Nature |volume=365 |issue= 6447 |pages= 666–9 |year= 1993 |pmid= 8105392 |doi= 10.1038/365666a0
*cite journal | author=Dubrovsky L, Ulrich P, Nuovo GJ, "et al." |title=Nuclear localization signal of HIV-1 as a novel target for therapeutic intervention. |journal=Mol. Med. |volume=1 |issue= 2 |pages= 217–30 |year= 1996 |pmid= 8529100 |doi=
*cite journal | author=Gallay P, Stitt V, Mundy C, "et al." |title=Role of the karyopherin pathway in human immunodeficiency virus type 1 nuclear import. |journal=J. Virol. |volume=70 |issue= 2 |pages= 1027–32 |year= 1996 |pmid= 8551560 |doi=
*cite journal | author=Bukrinskaya AG, Ghorpade A, Heinzinger NK, "et al." |title=Phosphorylation-dependent human immunodeficiency virus type 1 infection and nuclear targeting of viral DNA. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 1 |pages= 367–71 |year= 1996 |pmid= 8552640 |doi=
*cite journal | author=Sato A, Yoshimoto J, Isaka Y, "et al." |title=Evidence for direct association of Vpr and matrix protein p17 within the HIV-1 virion. |journal=Virology |volume=220 |issue= 1 |pages= 208–12 |year= 1996 |pmid= 8659115 |doi= 10.1006/viro.1996.0302
*cite journal | author=Popov S, Dubrovsky L, Lee MA, "et al." |title=Critical role of reverse transcriptase in the inhibitory mechanism of CNI-H0294 on HIV-1 nuclear translocation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 21 |pages= 11859–64 |year= 1996 |pmid= 8876228 |doi=
*cite journal | author=Freed EO, Englund G, Maldarelli F, Martin MA |title=Phosphorylation of residue 131 of HIV-1 matrix is not required for macrophage infection. |journal=Cell |volume=88 |issue= 2 |pages= 171–3; discussion 173–4 |year= 1997 |pmid= 9008157 |doi=
*cite journal | author=Gallay P, Hope T, Chin D, Trono D |title=HIV-1 infection of nondividing cells through the recognition of integrase by the importin/karyopherin pathway. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 18 |pages= 9825–30 |year= 1997 |pmid= 9275210 |doi=
*cite journal | author=Besançon F, Just J, Bourgeade MF, "et al." |title=HIV-1 p17 and IFN-gamma both induce fructose 1,6-bisphosphatase. |journal=J. Interferon Cytokine Res. |volume=17 |issue= 8 |pages= 461–7 |year= 1997 |pmid= 9282826 |doi=

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