Enzyme-thiol transhydrogenase (glutathione-disulfide)

Enzyme-thiol transhydrogenase (glutathione-disulfide)

In enzymology, an enzyme-thiol transhydrogenase (glutathione-disulfide) (EC number|1.8.4.7) is an enzyme that catalyzes the chemical reaction

: [xanthine dehydrogenase] + glutathione disulfide ightleftharpoons [xanthine oxidase] + 2 glutathione

Thus, the two substrates of this enzyme are [xanthine dehydrogenase] and glutathione disulfide, whereas its two products are [xanthine oxidase] and glutathione.

This enzyme belongs to the family of oxidoreductases, specifically those acting on a sulfur group of donors with a disulfide as acceptor. The systematic name of this enzyme class is [xanthine-dehydrogenase] :glutathione-disulfide S-oxidoreductase. Other names in common use include [xanthine-dehydrogenase] :oxidized-glutathione S-oxidoreductase, enzyme-thiol transhydrogenase (oxidized-glutathione), glutathione-dependent thiol:disulfide oxidoreductase, and thiol:disulfide oxidoreductase. This enzyme participates in glutathione metabolism.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|85030-79-1."

Gene Ontology (GO) codes


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