- Alanine dehydrogenase
In
enzymology , an alanine dehydrogenase (EC number|1.4.1.1) is anenzyme that catalyzes thechemical reaction :L-alanine + H2O + NAD+ pyruvate + NH3 + NADH + H+
The 3 substrates of this enzyme are
L-alanine , H2O, and NAD+, whereas its 4 products arepyruvate , NH3, NADH, and H+.This enzyme belongs to the family of
oxidoreductase s, specifically those acting on the CH-NH2 group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is L-alanine:NAD+ oxidoreductase (deaminating). Other names in common use include AlaDH, L-alanine dehydrogenase, NAD+-linked alanine dehydrogenase, alpha-alanine dehydrogenase, NAD+-dependent alanine dehydrogenase, alanine oxidoreductase, and NADH-dependent alanine dehydrogenase. This enzyme participates intaurine and hypotaurine metabolism andreductive carboxylate cycle (co2 fixation) .tructural studies
As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1OMO, PDB link|1PJB, PDB link|1PJC, PDB link|1SAY, PDB link|1VLL, and PDB link|2EEZ.
References
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*External links
::"The
CAS registry number for this enzyme class is CAS registry|9029-06-5."Gene Ontology (GO) codes
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