NCF2

Neutrophil cytosolic factor 2 (65kDa, chronic granulomatous disease, autosomal 2), also known as NCF2, is a human gene.

PBB_Summary
section_title =
summary_text = This gene encodes neutrophil cytosolic factor 2, the 67-kilodalton cytosolic subunit of the multi-protein complex known as NADPH oxidase found in neutrophils. This oxidase produces a burst of superoxide which is delivered to the lumen of the neutrophil phagosome. Mutations in this gene, as well as in other NADPH oxidase subunits, can result in chronic granulomatous disease.cite web | title = Entrez Gene: NCF2 neutrophil cytosolic factor 2 (65kDa, chronic granulomatous disease, autosomal 2)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4688| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Wientjes FB, Segal AW |title=NADPH oxidase and the respiratory burst. |journal=Semin. Cell Biol. |volume=6 |issue= 6 |pages= 357–65 |year= 1996 |pmid= 8748143 |doi=
*cite journal | author=DeLeo FR, Quinn MT |title=Assembly of the phagocyte NADPH oxidase: molecular interaction of oxidase proteins. |journal=J. Leukoc. Biol. |volume=60 |issue= 6 |pages= 677–91 |year= 1997 |pmid= 8975869 |doi=
*cite journal | author=Dorseuil O, Gacon G |title= [Signal transduction by Rac small G proteins in phagocytes] |journal=C. R. Seances Soc. Biol. Fil. |volume=191 |issue= 2 |pages= 237–46 |year= 1997 |pmid= 9255350 |doi=
*cite journal | author=Leto TL, Lomax KJ, Volpp BD, "et al." |title=Cloning of a 67-kD neutrophil oxidase factor with similarity to a noncatalytic region of p60c-src. |journal=Science |volume=248 |issue= 4956 |pages= 727–30 |year= 1990 |pmid= 1692159 |doi=
*cite journal | author=Kenney RT, Leto TL |title=A HindIII polymorphism in the human NCF2 gene. |journal=Nucleic Acids Res. |volume=18 |issue= 23 |pages= 7193 |year= 1991 |pmid= 1979859 |doi=
*cite journal | author=Francke U, Hsieh CL, Foellmer BE, "et al." |title=Genes for two autosomal recessive forms of chronic granulomatous disease assigned to 1q25 (NCF2) and 7q11.23 (NCF1). |journal=Am. J. Hum. Genet. |volume=47 |issue= 3 |pages= 483–92 |year= 1990 |pmid= 2393022 |doi=
*cite journal | author=Kenney RT, Malech HL, Epstein ND, "et al." |title=Characterization of the p67phox gene: genomic organization and restriction fragment length polymorphism analysis for prenatal diagnosis in chronic granulomatous disease. |journal=Blood |volume=82 |issue= 12 |pages= 3739–44 |year= 1994 |pmid= 7903171 |doi=
*cite journal | author=Leto TL, Adams AG, de Mendez I |title=Assembly of the phagocyte NADPH oxidase: binding of Src homology 3 domains to proline-rich targets. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 22 |pages= 10650–4 |year= 1994 |pmid= 7938008 |doi=
*cite journal | author=Dusi S, Rossi F |title=Activation of NADPH oxidase of human neutrophils involves the phosphorylation and the translocation of cytosolic p67phox. |journal=Biochem. J. |volume=296 ( Pt 2) |issue= |pages= 367–71 |year= 1994 |pmid= 8257426 |doi=
*cite journal | author=de Boer M, Hilarius-Stokman PM, Hossle JP, "et al." |title=Autosomal recessive chronic granulomatous disease with absence of the 67-kD cytosolic NADPH oxidase component: identification of mutation and detection of carriers. |journal=Blood |volume=83 |issue= 2 |pages= 531–6 |year= 1994 |pmid= 8286749 |doi=
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Bonizzato A, Russo MP, Donini M, Dusi S |title=Identification of a double mutation (D160V-K161E) in the p67phox gene of a chronic granulomatous disease patient. |journal=Biochem. Biophys. Res. Commun. |volume=231 |issue= 3 |pages= 861–3 |year= 1997 |pmid= 9070911 |doi= 10.1006/bbrc.1997.6204
*cite journal | author=Sathyamoorthy M, de Mendez I, Adams AG, Leto TL |title=p40(phox) down-regulates NADPH oxidase activity through interactions with its SH3 domain. |journal=J. Biol. Chem. |volume=272 |issue= 14 |pages= 9141–6 |year= 1997 |pmid= 9083043 |doi=
*cite journal | author=Ahmed S, Prigmore E, Govind S, "et al." |title=Cryptic Rac-binding and p21(Cdc42Hs/Rac)-activated kinase phosphorylation sites of NADPH oxidase component p67(phox). |journal=J. Biol. Chem. |volume=273 |issue= 25 |pages= 15693–701 |year= 1998 |pmid= 9624165 |doi=
*cite journal | author=Faris SL, Rinckel LA, Huang J, "et al." |title=Phagocyte NADPH oxidase p67-phox possesses a novel carboxylterminal binding site for the GTPases Rac2 and Cdc42. |journal=Biochem. Biophys. Res. Commun. |volume=247 |issue= 2 |pages= 271–6 |year= 1998 |pmid= 9642115 |doi= 10.1006/bbrc.1998.8775
*cite journal | author=Rinckel LA, Faris SL, Hitt ND, Kleinberg ME |title=Rac1 disrupts p67phox/p40phox binding: a novel role for Rac in NADPH oxidase activation. |journal=Biochem. Biophys. Res. Commun. |volume=263 |issue= 1 |pages= 118–22 |year= 1999 |pmid= 10486263 |doi= 10.1006/bbrc.1999.1334
*cite journal | author=Patiño PJ, Rae J, Noack D, "et al." |title=Molecular characterization of autosomal recessive chronic granulomatous disease caused by a defect of the nicotinamide adenine dinucleotide phosphate (reduced form) oxidase component p67-phox. |journal=Blood |volume=94 |issue= 7 |pages= 2505–14 |year= 1999 |pmid= 10498624 |doi=

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