ACTR3

ARP3 actin-related protein 3 homolog (yeast), also known as ACTR3, is a human gene.

PBB_Summary
section_title =
summary_text = The specific function of this gene has not yet been determined; however, the protein it encodes is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and motility through lamellipodial actin assembly and protrusion.cite web | title = Entrez Gene: ACTR3 ARP3 actin-related protein 3 homolog (yeast)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10096| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Welch MD, Iwamatsu A, Mitchison TJ |title=Actin polymerization is induced by Arp2/3 protein complex at the surface of Listeria monocytogenes. |journal=Nature |volume=385 |issue= 6613 |pages= 265–9 |year= 1997 |pmid= 9000076 |doi= 10.1038/385265a0
*cite journal | author=Winter D, Podtelejnikov AV, Mann M, Li R |title=The complex containing actin-related proteins Arp2 and Arp3 is required for the motility and integrity of yeast actin patches. |journal=Curr. Biol. |volume=7 |issue= 7 |pages= 519–29 |year= 1997 |pmid= 9210376 |doi=
*cite journal | author=Welch MD, DePace AH, Verma S, "et al." |title=The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly. |journal=J. Cell Biol. |volume=138 |issue= 2 |pages= 375–84 |year= 1997 |pmid= 9230079 |doi=
*cite journal | author=Machesky LM, Reeves E, Wientjes F, "et al." |title=Mammalian actin-related protein 2/3 complex localizes to regions of lamellipodial protrusion and is composed of evolutionarily conserved proteins. |journal=Biochem. J. |volume=328 ( Pt 1) |issue= |pages= 105–12 |year= 1998 |pmid= 9359840 |doi=
*cite journal | author=Ma L, Rohatgi R, Kirschner MW |title=The Arp2/3 complex mediates actin polymerization induced by the small GTP-binding protein Cdc42. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 26 |pages= 15362–7 |year= 1999 |pmid= 9860974 |doi=
*cite journal | author=Machesky LM, Insall RH |title=Scar1 and the related Wiskott-Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complex. |journal=Curr. Biol. |volume=8 |issue= 25 |pages= 1347–56 |year= 1999 |pmid= 9889097 |doi=
*cite journal | author=Suetsugu S, Miki H, Takenawa T |title=Identification of two human WAVE/SCAR homologues as general actin regulatory molecules which associate with the Arp2/3 complex. |journal=Biochem. Biophys. Res. Commun. |volume=260 |issue= 1 |pages= 296–302 |year= 1999 |pmid= 10381382 |doi= 10.1006/bbrc.1999.0894
*cite journal | author=May RC, Hall ME, Higgs HN, "et al." |title=The Arp2/3 complex is essential for the actin-based motility of Listeria monocytogenes. |journal=Curr. Biol. |volume=9 |issue= 14 |pages= 759–62 |year= 1999 |pmid= 10421578 |doi=
*cite journal | author=Loisel TP, Boujemaa R, Pantaloni D, Carlier MF |title=Reconstitution of actin-based motility of Listeria and Shigella using pure proteins. |journal=Nature |volume=401 |issue= 6753 |pages= 613–6 |year= 1999 |pmid= 10524632 |doi= 10.1038/44183
*cite journal | author=Higgs HN, Blanchoin L, Pollard TD |title=Influence of the C terminus of Wiskott-Aldrich syndrome protein (WASp) and the Arp2/3 complex on actin polymerization. |journal=Biochemistry |volume=38 |issue= 46 |pages= 15212–22 |year= 1999 |pmid= 10563804 |doi=
*cite journal | author=Carlier MF, Nioche P, Broutin-L'Hermite I, "et al." |title=GRB2 links signaling to actin assembly by enhancing interaction of neural Wiskott-Aldrich syndrome protein (N-WASp) with actin-related protein (ARP2/3) complex. |journal=J. Biol. Chem. |volume=275 |issue= 29 |pages= 21946–52 |year= 2000 |pmid= 10781580 |doi= 10.1074/jbc.M000687200
*cite journal | author=Jay P, Bergé-Lefranc JL, Massacrier A, "et al." |title=ARP3beta, the gene encoding a new human actin-related protein, is alternatively spliced and predominantly expressed in brain neuronal cells. |journal=Eur. J. Biochem. |volume=267 |issue= 10 |pages= 2921–8 |year= 2000 |pmid= 10806390 |doi=
*cite journal | author=Weed SA, Karginov AV, Schafer DA, "et al." |title=Cortactin localization to sites of actin assembly in lamellipodia requires interactions with F-actin and the Arp2/3 complex. |journal=J. Cell Biol. |volume=151 |issue= 1 |pages= 29–40 |year= 2000 |pmid= 11018051 |doi=
*cite journal | author=Prehoda KE, Scott JA, Mullins RD, Lim WA |title=Integration of multiple signals through cooperative regulation of the N-WASP-Arp2/3 complex. |journal=Science |volume=290 |issue= 5492 |pages= 801–6 |year= 2000 |pmid= 11052943 |doi=
*cite journal | author=Marchand JB, Kaiser DA, Pollard TD, Higgs HN |title=Interaction of WASP/Scar proteins with actin and vertebrate Arp2/3 complex. |journal=Nat. Cell Biol. |volume=3 |issue= 1 |pages= 76–82 |year= 2001 |pmid= 11146629 |doi= 10.1038/35050590
*cite journal | author=Zhao X, Yang Z, Qian M, Zhu X |title=Interactions among subunits of human Arp2/3 complex: p20-Arc as the hub. |journal=Biochem. Biophys. Res. Commun. |volume=280 |issue= 2 |pages= 513–7 |year= 2001 |pmid= 11162547 |doi= 10.1006/bbrc.2000.4151
*cite journal | author=Robinson RC, Turbedsky K, Kaiser DA, "et al." |title=Crystal structure of Arp2/3 complex. |journal=Science |volume=294 |issue= 5547 |pages= 1679–84 |year= 2001 |pmid= 11721045 |doi= 10.1126/science.1066333
*cite journal | author=Gournier H, Goley ED, Niederstrasser H, "et al." |title=Reconstitution of human Arp2/3 complex reveals critical roles of individual subunits in complex structure and activity. |journal=Mol. Cell |volume=8 |issue= 5 |pages= 1041–52 |year= 2002 |pmid= 11741539 |doi=
*cite journal | author=Andersen JS, Lyon CE, Fox AH, "et al." |title=Directed proteomic analysis of the human nucleolus. |journal=Curr. Biol. |volume=12 |issue= 1 |pages= 1–11 |year= 2002 |pmid= 11790298 |doi=
*cite journal | author=Kovacs EM, Goodwin M, Ali RG, "et al." |title=Cadherin-directed actin assembly: E-cadherin physically associates with the Arp2/3 complex to direct actin assembly in nascent adhesive contacts. |journal=Curr. Biol. |volume=12 |issue= 5 |pages= 379–82 |year= 2002 |pmid= 11882288 |doi=

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