4-cresol dehydrogenase (hydroxylating)

4-cresol dehydrogenase (hydroxylating)

In enzymology, a 4-cresol dehydrogenase (hydroxylating) (EC number|1.17.99.1) is an enzyme that catalyzes the chemical reaction

:4-cresol + acceptor + H2O ightleftharpoons 4-hydroxybenzaldehyde + reduced acceptor

The 3 substrates of this enzyme are 4-cresol, acceptor, and H2O, whereas its two products are 4-hydroxybenzaldehyde and reduced acceptor.

This enzyme belongs to the family of oxidoreductases, specifically those acting on CH or CH2 group with other acceptors. The systematic name of this enzyme class is 4-cresol:acceptor oxidoreductase (methyl-hydroxylating). Other names in common use include p-cresol-(acceptor) oxidoreductase (hydroxylating), and p-cresol methylhydroxylase. This enzyme participates in toluene and xylene degradation. It has 2 cofactors: FAD, and Cytochrome c.

tructural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1DII, PDB link|1DIQ, PDB link|1WVE, and PDB link|1WVF.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|66772-07-4."

Gene Ontology (GO) codes


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  • List of EC numbers (EC 1) — This list contains a list of EC numbers for the first group, EC 1, oxidoreducatases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology.EC 1.1 Acting on the CH OH …   Wikipedia

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