TFPI2

TFPI2

Tissue factor pathway inhibitor 2, also known as TFPI2, is a human gene. [cite web | title = Entrez Gene: TFPI2 tissue factor pathway inhibitor 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=retrieve&dopt=default&list_uids=7980&rn=1| accessdate = ]

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References

Further reading

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*cite journal | author=Bützow R, Huhtala ML, Bohn H, "et al." |title=Purification and characterization of placental protein 5. |journal=Biochem. Biophys. Res. Commun. |volume=150 |issue= 1 |pages= 483–90 |year= 1988 |pmid= 3276312 |doi=
*cite journal | author=Takayama M, Soma H, Saito T, "et al." |title=Circulating levels of placental protein 5 in normal and abnormal pregnancies. |journal=Gynecol. Obstet. Invest. |volume=16 |issue= 1 |pages= 13–26 |year= 1983 |pmid= 6884838 |doi=
*cite journal | author=Miyagi Y, Koshikawa N, Yasumitsu H, "et al." |title=cDNA cloning and mRNA expression of a serine proteinase inhibitor secreted by cancer cells: identification as placental protein 5 and tissue factor pathway inhibitor-2. |journal=J. Biochem. |volume=116 |issue= 5 |pages= 939–42 |year= 1995 |pmid= 7896752 |doi=
*cite journal | author=Sprecher CA, Kisiel W, Mathewes S, Foster DC |title=Molecular cloning, expression, and partial characterization of a second human tissue-factor-pathway inhibitor. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 8 |pages= 3353–7 |year= 1994 |pmid= 8159751 |doi=
*cite journal | author=Petersen LC, Sprecher CA, Foster DC, "et al." |title=Inhibitory properties of a novel human Kunitz-type protease inhibitor homologous to tissue factor pathway inhibitor. |journal=Biochemistry |volume=35 |issue= 1 |pages= 266–72 |year= 1996 |pmid= 8555184 |doi= 10.1021/bi951501d
*cite journal | author=Miyagi Y, Yasumitsu H, Eki T, "et al." |title=Assignment of the human PP5/TFPI-2 gene to 7q22 by FISH and PCR-based human/rodent cell hybrid mapping panel analysis. |journal=Genomics |volume=35 |issue= 1 |pages= 267–8 |year= 1996 |pmid= 8661135 |doi= 10.1006/geno.1996.0353
*cite journal | author=Rao CN, Reddy P, Liu Y, "et al." |title=Extracellular matrix-associated serine protease inhibitors (Mr 33,000, 31,000, and 27,000) are single-gene products with differential glycosylation: cDNA cloning of the 33-kDa inhibitor reveals its identity to tissue factor pathway inhibitor-2. |journal=Arch. Biochem. Biophys. |volume=335 |issue= 1 |pages= 82–92 |year= 1996 |pmid= 8914837 |doi= 10.1006/abbi.1996.0484
*cite journal | author=Miyagi Y, Yasumitsu H, Mizushima H, "et al." |title=Cloning of the cDNA encoding mouse PP5/TFPI-2 and mapping of the gene to chromosome 6. |journal=DNA Cell Biol. |volume=15 |issue= 11 |pages= 947–54 |year= 1997 |pmid= 8945635 |doi=
*cite journal | author=Iino M, Foster DC, Kisiel W |title=Quantification and characterization of human endothelial cell-derived tissue factor pathway inhibitor-2. |journal=Arterioscler. Thromb. Vasc. Biol. |volume=18 |issue= 1 |pages= 40–6 |year= 1998 |pmid= 9445254 |doi=
*cite journal | author=Udagawa K, Miyagi Y, Hirahara F, "et al." |title=Specific expression of PP5/TFPI2 mRNA by syncytiotrophoblasts in human placenta as revealed by in situ hybridization. |journal=Placenta |volume=19 |issue= 2-3 |pages= 217–23 |year= 1998 |pmid= 9548189 |doi=
*cite journal | author=Shinoda E, Yui Y, Hattori R, "et al." |title=Tissue factor pathway inhibitor-2 is a novel mitogen for vascular smooth muscle cells. |journal=J. Biol. Chem. |volume=274 |issue= 9 |pages= 5379–84 |year= 1999 |pmid= 10026147 |doi=
*cite journal | author=Liu Y, Stack SM, Lakka SS, "et al." |title=Matrix localization of tissue factor pathway inhibitor-2/matrix-associated serine protease inhibitor (TFPI-2/MSPI) involves arginine-mediated ionic interactions with heparin and dermatan sulfate: heparin accelerates the activity of TFPI-2/MSPI toward plasmin. |journal=Arch. Biochem. Biophys. |volume=370 |issue= 1 |pages= 112–8 |year= 1999 |pmid= 10496984 |doi= 10.1006/abbi.1999.1371
*cite journal | author=Kamei S, Kazama Y, Kuijper JL, "et al." |title=Genomic structure and promoter activity of the human tissue factor pathway inhibitor-2 gene. |journal=Biochim. Biophys. Acta |volume=1517 |issue= 3 |pages= 430–5 |year= 2001 |pmid= 11342222 |doi=
*cite journal | author=Crawley JT, Goulding DA, Ferreira V, "et al." |title=Expression and localization of tissue factor pathway inhibitor-2 in normal and atherosclerotic human vessels. |journal=Arterioscler. Thromb. Vasc. Biol. |volume=22 |issue= 2 |pages= 218–24 |year= 2002 |pmid= 11834519 |doi=
*cite journal | author=Konduri SD, Osman FA, Rao CN, "et al." |title=Minimal and inducible regulation of tissue factor pathway inhibitor-2 in human gliomas. |journal=Oncogene |volume=21 |issue= 6 |pages= 921–8 |year= 2002 |pmid= 11840337 |doi= 10.1038/sj.onc.1204983
*cite journal | author=Udagawa K, Yasumitsu H, Esaki M, "et al." |title=Subcellular localization of PP5/TFPI-2 in human placenta: a possible role of PP5/TFPI-2 as an anti-coagulant on the surface of syncytiotrophoblasts. |journal=Placenta |volume=23 |issue= 2-3 |pages= 145–53 |year= 2002 |pmid= 11945080 |doi= 10.1053/plac.2001.0774
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Hubé F, Reverdiau P, Iochmann S, "et al." |title=Demonstration of a tissue factor pathway inhibitor 2 messenger RNA synthesis by pure villous cytotrophoblast cells isolated from term human placentas. |journal=Biol. Reprod. |volume=68 |issue= 5 |pages= 1888–94 |year= 2003 |pmid= 12606321 |doi= 10.1095/biolreprod.102.011858
*cite journal | author=George J, Gondi CS, Dinh DH, Gujrati M, Rao JS.|title=Restoration of tissue factor pathway inhibitor-2 in a human glioblastoma cell line triggers caspase-mediated pathway and apoptosis. |journal=Clin Cancer Res. |volume=13|issue= 12 |pages= 3507-3517. |year= 2007 |pmid= 17575213 |doi= 10.1158/1078-0432.CCR-06-3023
*cite journal | author=Rao CN, Segawa T, Navari JR, "et al." |title=Methylation of TFPI-2 gene is not the sole cause of its silencing. |journal=Int. J. Oncol. |volume=22 |issue= 4 |pages= 843–8 |year= 2003 |pmid= 12632077 |doi=
*cite journal | author=Scherer SW, Cheung J, MacDonald JR, "et al." |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767–72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423

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  • Tissue factor pathway inhibitor — (or TFPI) is a single chain polypeptide which can reversibly inhibit Factor Xa (Xa). While Xa is inhibited, the Xa TFPI complex can subsequently also inhibit the FVIIa TF complex.TFPI contributes significantly to the inhibition of Xa in vivo,… …   Wikipedia

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