RNASEL

Ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent), also known as RNASEL, is a human gene.

PBB_Summary
section_title =
summary_text = This gene encodes a component of the interferon-regulated 2-5A system that functions in the antiviral and antiproliferative roles of interferons. Mutations in this gene have been associated with predisposition to prostate cancer and this gene is a candidate for the hereditary prostate cancer 1 (HPC1) allele.cite web | title = Entrez Gene: RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6041| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Castelli J, Wood KA, Youle RJ |title=The 2-5A system in viral infection and apoptosis. |journal=Biomed. Pharmacother. |volume=52 |issue= 9 |pages= 386–90 |year= 1999 |pmid= 9856285 |doi=
*cite journal | author=Leaman DW, Cramer H |title=Controlling gene expression with 2-5A antisense. |journal=Methods |volume=18 |issue= 3 |pages= 252–65 |year= 1999 |pmid= 10454983 |doi= 10.1006/meth.1999.0782
*cite journal | author=Silverman RH |title=Implications for RNase L in prostate cancer biology. |journal=Biochemistry |volume=42 |issue= 7 |pages= 1805–12 |year= 2003 |pmid= 12590567 |doi= 10.1021/bi027147i
*cite journal | author=Kieffer N, Schmitz M, Scheiden R, "et al." |title=Involvement of the RNAse L gene in prostate cancer. |journal=Bulletin de la Société des sciences médicales du Grand-Duché de Luxembourg |volume= |issue= 1 |pages= 21–8 |year= 2006 |pmid= 16869093 |doi=
*cite journal | author=Bisbal C, Silverman RH |title=Diverse functions of RNase L and implications in pathology. |journal=Biochimie |volume=89 |issue= 6-7 |pages= 789–98 |year= 2007 |pmid= 17400356 |doi= 10.1016/j.biochi.2007.02.006
*cite journal | author=Carter BS, Beaty TH, Steinberg GD, "et al." |title=Mendelian inheritance of familial prostate cancer. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 8 |pages= 3367–71 |year= 1992 |pmid= 1565627 |doi=
*cite journal | author=Squire J, Zhou A, Hassel BA, "et al." |title=Localization of the interferon-induced, 2-5A-dependent RNase gene (RNS4) to human chromosome 1q25. |journal=Genomics |volume=19 |issue= 1 |pages= 174–5 |year= 1994 |pmid= 7514564 |doi= 10.1006/geno.1994.1033
*cite journal | author=Dong B, Xu L, Zhou A, "et al." |title=Intrinsic molecular activities of the interferon-induced 2-5A-dependent RNase. |journal=J. Biol. Chem. |volume=269 |issue= 19 |pages= 14153–8 |year= 1994 |pmid= 7514601 |doi=
*cite journal | author=Bisbal C, Martinand C, Silhol M, "et al." |title=Cloning and characterization of a RNAse L inhibitor. A new component of the interferon-regulated 2-5A pathway. |journal=J. Biol. Chem. |volume=270 |issue= 22 |pages= 13308–17 |year= 1995 |pmid= 7539425 |doi=
*cite journal | author=Zhou A, Hassel BA, Silverman RH |title=Expression cloning of 2-5A-dependent RNAase: a uniquely regulated mediator of interferon action. |journal=Cell |volume=72 |issue= 5 |pages= 753–65 |year= 1993 |pmid= 7680958 |doi=
*cite journal | author=Hassel BA, Zhou A, Sotomayor C, "et al." |title=A dominant negative mutant of 2-5A-dependent RNase suppresses antiproliferative and antiviral effects of interferon. |journal=EMBO J. |volume=12 |issue= 8 |pages= 3297–304 |year= 1993 |pmid= 7688298 |doi=
*cite journal | author=Smith JR, Freije D, Carpten JD, "et al." |title=Major susceptibility locus for prostate cancer on chromosome 1 suggested by a genome-wide search. |journal=Science |volume=274 |issue= 5291 |pages= 1371–4 |year= 1996 |pmid= 8910276 |doi=
*cite journal | author=Egesten A, Dyer KD, Batten D, "et al." |title=Ribonucleases and host defense: identification, localization and gene expression in adherent monocytes in vitro. |journal=Biochim. Biophys. Acta |volume=1358 |issue= 3 |pages= 255–60 |year= 1997 |pmid= 9366257 |doi=
*cite journal | author=Eeles RA, Durocher F, Edwards S, "et al." |title=Linkage analysis of chromosome 1q markers in 136 prostate cancer families. The Cancer Research Campaign/British Prostate Group U.K. Familial Prostate Cancer Study Collaborators. |journal=Am. J. Hum. Genet. |volume=62 |issue= 3 |pages= 653–8 |year= 1998 |pmid= 9497242 |doi=
*cite journal | author=Dong B, Silverman RH |title=Alternative function of a protein kinase homology domain in 2', 5'-oligoadenylate dependent RNase L. |journal=Nucleic Acids Res. |volume=27 |issue= 2 |pages= 439–45 |year= 1999 |pmid= 9862963 |doi=
*cite journal | author=Carpten JD, Makalowska I, Robbins CM, "et al." |title=A 6-Mb high-resolution physical and transcription map encompassing the hereditary prostate cancer 1 (HPC1) region. |journal=Genomics |volume=64 |issue= 1 |pages= 1–14 |year= 2000 |pmid= 10708513 |doi= 10.1006/geno.1999.6051
*cite journal | author=Zhou A, Nie H, Silverman RH |title=Analysis and origins of the human and mouse RNase L genes: mediators of interferon action. |journal=Mamm. Genome |volume=11 |issue= 11 |pages= 989–92 |year= 2001 |pmid= 11063255 |doi=
*cite journal | author=Dong B, Niwa M, Walter P, Silverman RH |title=Basis for regulated RNA cleavage by functional analysis of RNase L and Ire1p. |journal=RNA |volume=7 |issue= 3 |pages= 361–73 |year= 2001 |pmid= 11333017 |doi=

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