KPNA4

Karyopherin alpha 4 (importin alpha 3), also known as KPNA4, is a human gene.

PBB_Summary
section_title =
summary_text = The nuclear import of karyophilic proteins is directed by short amino acid sequences termed nuclear localization signals (NLSs). Karyopherins, or importins, are cytoplasmic proteins that recognize NLSs and dock NLS-containing proteins to the nuclear pore complex. The protein encoded by this gene shares the sequence similarity with Xenopus importin-alpha and Saccharomyces cerevisiae Srp1. This protein is found to interact with the NLSs of DNA helicase Q1 and SV40 T antigen.cite web | title = Entrez Gene: KPNA4 karyopherin alpha 4 (importin alpha 3)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3840| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Bukrinsky MI, Haffar OK |title=HIV-1 nuclear import: in search of a leader. |journal=Front. Biosci. |volume=2 |issue= |pages= d578–87 |year= 2004 |pmid= 9366553 |doi=
*cite journal | author=Bukrinsky MI, Haffar OK |title=HIV-1 nuclear import: matrix protein is back on center stage, this time together with Vpr. |journal=Mol. Med. |volume=4 |issue= 3 |pages= 138–43 |year= 1998 |pmid= 9562972 |doi=
*cite journal | author=Bukrinsky MI, Sharova N, Dempsey MP, "et al." |title=Active nuclear import of human immunodeficiency virus type 1 preintegration complexes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 14 |pages= 6580–4 |year= 1992 |pmid= 1631159 |doi=
*cite journal | author=Sharova N, Bukrinskaya A |title=p17 and p17-containing gag precursors of input human immunodeficiency virus are transported into the nuclei of infected cells. |journal=AIDS Res. Hum. Retroviruses |volume=7 |issue= 3 |pages= 303–6 |year= 1991 |pmid= 2064827 |doi=
*cite journal | author=Di Marzio P, Choe S, Ebright M, "et al." |title=Mutational analysis of cell cycle arrest, nuclear localization and virion packaging of human immunodeficiency virus type 1 Vpr. |journal=J. Virol. |volume=69 |issue= 12 |pages= 7909–16 |year= 1996 |pmid= 7494303 |doi=
*cite journal | author=Gallay P, Swingler S, Song J, "et al." |title=HIV nuclear import is governed by the phosphotyrosine-mediated binding of matrix to the core domain of integrase. |journal=Cell |volume=83 |issue= 4 |pages= 569–76 |year= 1995 |pmid= 7585960 |doi=
*cite journal | author=Freed EO, Englund G, Martin MA |title=Role of the basic domain of human immunodeficiency virus type 1 matrix in macrophage infection. |journal=J. Virol. |volume=69 |issue= 6 |pages= 3949–54 |year= 1995 |pmid= 7745752 |doi=
*cite journal | author=Gallay P, Swingler S, Aiken C, Trono D |title=HIV-1 infection of nondividing cells: C-terminal tyrosine phosphorylation of the viral matrix protein is a key regulator. |journal=Cell |volume=80 |issue= 3 |pages= 379–88 |year= 1995 |pmid= 7859280 |doi=
*cite journal | author=von Schwedler U, Kornbluth RS, Trono D |title=The nuclear localization signal of the matrix protein of human immunodeficiency virus type 1 allows the establishment of infection in macrophages and quiescent T lymphocytes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 15 |pages= 6992–6 |year= 1994 |pmid= 8041734 |doi=
*cite journal | author=Heinzinger NK, Bukinsky MI, Haggerty SA, "et al." |title=The Vpr protein of human immunodeficiency virus type 1 influences nuclear localization of viral nucleic acids in nondividing host cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 15 |pages= 7311–5 |year= 1994 |pmid= 8041786 |doi=
*cite journal | author=Bukrinsky MI, Haggerty S, Dempsey MP, "et al." |title=A nuclear localization signal within HIV-1 matrix protein that governs infection of non-dividing cells. |journal=Nature |volume=365 |issue= 6447 |pages= 666–9 |year= 1993 |pmid= 8105392 |doi= 10.1038/365666a0
*cite journal | author=Dubrovsky L, Ulrich P, Nuovo GJ, "et al." |title=Nuclear localization signal of HIV-1 as a novel target for therapeutic intervention. |journal=Mol. Med. |volume=1 |issue= 2 |pages= 217–30 |year= 1996 |pmid= 8529100 |doi=
*cite journal | author=Gallay P, Stitt V, Mundy C, "et al." |title=Role of the karyopherin pathway in human immunodeficiency virus type 1 nuclear import. |journal=J. Virol. |volume=70 |issue= 2 |pages= 1027–32 |year= 1996 |pmid= 8551560 |doi=
*cite journal | author=Bukrinskaya AG, Ghorpade A, Heinzinger NK, "et al." |title=Phosphorylation-dependent human immunodeficiency virus type 1 infection and nuclear targeting of viral DNA. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 1 |pages= 367–71 |year= 1996 |pmid= 8552640 |doi=
*cite journal | author=Sato A, Yoshimoto J, Isaka Y, "et al." |title=Evidence for direct association of Vpr and matrix protein p17 within the HIV-1 virion. |journal=Virology |volume=220 |issue= 1 |pages= 208–12 |year= 1996 |pmid= 8659115 |doi= 10.1006/viro.1996.0302
*cite journal | author=Popov S, Dubrovsky L, Lee MA, "et al." |title=Critical role of reverse transcriptase in the inhibitory mechanism of CNI-H0294 on HIV-1 nuclear translocation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 21 |pages= 11859–64 |year= 1996 |pmid= 8876228 |doi=
*cite journal | author=Freed EO, Englund G, Maldarelli F, Martin MA |title=Phosphorylation of residue 131 of HIV-1 matrix is not required for macrophage infection. |journal=Cell |volume=88 |issue= 2 |pages= 171–3; discussion 173–4 |year= 1997 |pmid= 9008157 |doi=
*cite journal | author=Seki T, Tada S, Katada T, Enomoto T |title=Cloning of a cDNA encoding a novel importin-alpha homologue, Qip1: discrimination of Qip1 and Rch1 from hSrp1 by their ability to interact with DNA helicase Q1/RecQL. |journal=Biochem. Biophys. Res. Commun. |volume=234 |issue= 1 |pages= 48–53 |year= 1997 |pmid= 9168958 |doi= 10.1006/bbrc.1997.6535
*cite journal | author=Gallay P, Hope T, Chin D, Trono D |title=HIV-1 infection of nondividing cells through the recognition of integrase by the importin/karyopherin pathway. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 18 |pages= 9825–30 |year= 1997 |pmid= 9275210 |doi=
*cite journal | author=Besançon F, Just J, Bourgeade MF, "et al." |title=HIV-1 p17 and IFN-gamma both induce fructose 1,6-bisphosphatase. |journal=J. Interferon Cytokine Res. |volume=17 |issue= 8 |pages= 461–7 |year= 1997 |pmid= 9282826 |doi=

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes