PBEF1

Pre-B-cell colony enhancing factor 1, also known as PBEF1, is a human gene.

PBB_Summary
section_title =
summary_text = This gene encodes a protein that catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, one step in the biosynthesis of nicotinamide adenine dinucleotide. The protein is an adipokine that is localized to the bloodstream and has various functions, including the promotion of vascular smooth muscle cell maturation and inhibition of neutrophil apoptosis. It also activates insulin receptor and has insulin-mimetic effects, lowering blood glucose and improving insulin sensitivity. The protein is highly expressed in visceral fat and serum levels of the protein correlate with obesity. This gene has a pseudogene on chromosome 10.cite web | title = Entrez Gene: PBEF1 pre-B-cell colony enhancing factor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10135| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Stephens JM, Vidal-Puig AJ |title=An update on visfatin/pre-B cell colony-enhancing factor, an ubiquitously expressed, illusive cytokine that is regulated in obesity. |journal=Curr. Opin. Lipidol. |volume=17 |issue= 2 |pages= 128–31 |year= 2007 |pmid= 16531748 |doi= 10.1097/01.mol.0000217893.77746.4b
*cite journal | author=Bełtowski J |title=Apelin and visfatin: unique "beneficial" adipokines upregulated in obesity? |journal=Med. Sci. Monit. |volume=12 |issue= 6 |pages= RA112–9 |year= 2006 |pmid= 16733497 |doi=
*cite journal | author=Pilz S, Mangge H, Obermayer-Pietsch B, März W |title=Visfatin/pre-B-cell colony-enhancing factor: a protein with various suggested functions. |journal=J. Endocrinol. Invest. |volume=30 |issue= 2 |pages= 138–44 |year= 2007 |pmid= 17392604 |doi=
*cite journal | author=Siderovski DP, Blum S, Forsdyke RE, Forsdyke DR |title=A set of human putative lymphocyte G0/G1 switch genes includes genes homologous to rodent cytokine and zinc finger protein-encoding genes. |journal=DNA Cell Biol. |volume=9 |issue= 8 |pages= 579–87 |year= 1991 |pmid= 1702972 |doi=
*cite journal | author=Samal B, Sun Y, Stearns G, "et al." |title=Cloning and characterization of the cDNA encoding a novel human pre-B-cell colony-enhancing factor. |journal=Mol. Cell. Biol. |volume=14 |issue= 2 |pages= 1431–7 |year= 1994 |pmid= 8289818 |doi=
*cite journal | author= |title=Toward a complete human genome sequence. |journal=Genome Res. |volume=8 |issue= 11 |pages= 1097–108 |year= 1999 |pmid= 9847074 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Rongvaux A, Shea RJ, Mulks MH, "et al." |title=Pre-B-cell colony-enhancing factor, whose expression is up-regulated in activated lymphocytes, is a nicotinamide phosphoribosyltransferase, a cytosolic enzyme involved in NAD biosynthesis. |journal=Eur. J. Immunol. |volume=32 |issue= 11 |pages= 3225–34 |year= 2003 |pmid= 12555668 |doi= 10.1002/1521-4141(200211)32:11<3225::AID-IMMU3225>3.0.CO;2-L |doilabel=10.1002/1521-4141(200211)32:113225::AID-IMMU32253.0.CO;2-L
*cite journal | author=Scherer SW, Cheung J, MacDonald JR, "et al." |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767–72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423
*cite journal | author=Kitani T, Okuno S, Fujisawa H |title=Growth phase-dependent changes in the subcellular localization of pre-B-cell colony-enhancing factor. |journal=FEBS Lett. |volume=544 |issue= 1-3 |pages= 74–8 |year= 2003 |pmid= 12782293 |doi=
*cite journal | author=Hillier LW, Fulton RS, Fulton LA, "et al." |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157–64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782
*cite journal | author=Reuter TY, Medhurst AL, Waisfisz Q, "et al." |title=Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport. |journal=Exp. Cell Res. |volume=289 |issue= 2 |pages= 211–21 |year= 2003 |pmid= 14499622 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Jia SH, Li Y, Parodo J, "et al." |title=Pre-B cell colony-enhancing factor inhibits neutrophil apoptosis in experimental inflammation and clinical sepsis. |journal=J. Clin. Invest. |volume=113 |issue= 9 |pages= 1318–27 |year= 2004 |pmid= 15124023 |doi= 10.1172/JCI200419930
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Rush J, Moritz A, Lee KA, "et al." |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94–101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046
*cite journal | author=Fukuhara A, Matsuda M, Nishizawa M, "et al." |title=Visfatin: a protein secreted by visceral fat that mimics the effects of insulin. |journal=Science |volume=307 |issue= 5708 |pages= 426–30 |year= 2005 |pmid= 15604363 |doi= 10.1126/science.1097243
*cite journal | author=Janssen JJ, Klaver SM, Waisfisz Q, "et al." |title=Identification of genes potentially involved in disease transformation of CML. |journal=Leukemia |volume=19 |issue= 6 |pages= 998–1004 |year= 2005 |pmid= 15815727 |doi= 10.1038/sj.leu.2403735
*cite journal | author=van der Veer E, Nong Z, O'Neil C, "et al." |title=Pre-B-cell colony-enhancing factor regulates NAD+-dependent protein deacetylase activity and promotes vascular smooth muscle cell maturation. |journal=Circ. Res. |volume=97 |issue= 1 |pages= 25–34 |year= 2005 |pmid= 15947248 |doi= 10.1161/01.RES.0000173298.38808.27
*cite journal | author=Ognjanovic S, Ku TL, Bryant-Greenwood GD |title=Pre-B-cell colony-enhancing factor is a secreted cytokine-like protein from the human amniotic epithelium. |journal=Am. J. Obstet. Gynecol. |volume=193 |issue= 1 |pages= 273–82 |year= 2005 |pmid= 16021090 |doi= 10.1016/j.ajog.2004.11.003

PBB_Controls
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