Aldehyde dehydrogenase (NAD(P)+)
- Aldehyde dehydrogenase (NAD(P)+)
In enzymology, an aldehyde dehydrogenase [NAD(P)+] (EC number|1.2.1.5) is an enzyme that catalyzes the chemical reaction
:an aldehyde + NAD(P)+ + H2O an acid + NAD(P)H + H+
The 4 substrates of this enzyme are aldehyde, NAD+, NADP+, and H2O, whereas its 4 products are acid, NADH, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is aldehyde:NAD(P)+ oxidoreductase. Other names in common use include aldehyde dehydrogenase [NAD(P)+] , and ALDH. This enzyme participates in 5 metabolic pathways: glycolysis / gluconeogenesis, histidine metabolism, tyrosine metabolism, phenylalanine metabolism, and metabolism of xenobiotics by cytochrome p450.
tructural studies
As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1AD3, PDB link|1EYY, PDB link|1EZ0, and PDB link|2AMF.
References
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* Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 7, Academic Press, New York, 1963, p. 203-221.
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External links
::"The CAS registry number for this enzyme class is CAS registry|9028-88-0."
Gene Ontology (GO) codes
Wikimedia Foundation.
2010.
Look at other dictionaries:
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