McComb can refer to:
- McComb, Mississippi
- McComb, Ohio (which was named for Alexander Macomb (American general)
- McComb Local School District, Hancock County, Ohio
- McComb High School (Ohio)
- Heather McComb, actress
- David McComb, musician
- Billy McComb, magician and comedian
- Colin McComb, writer and game designer
- Frank McComb, jazz singer
- John McComb, Jr., architect
- Eleazer McComb, merchant
- William McComb, Confederate Brigadier General
- McCombs (disambiguation)
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