CCND3

Cyclin D3, also known as CCND3, is a human gene.

PBB_Summary
section_title =
summary_text = The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation. [cite web | title = Entrez Gene: CCND3 cyclin D3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=896| accessdate = ]

ee also

* Cyclin
* Cyclin D

References

PBB_Further_reading
citations =
*cite journal | author=Motokura T, Keyomarsi K, Kronenberg HM, Arnold A |title=Cloning and characterization of human cyclin D3, a cDNA closely related in sequence to the PRAD1/cyclin D1 proto-oncogene. |journal=J. Biol. Chem. |volume=267 |issue= 28 |pages= 20412–5 |year= 1992 |pmid= 1383201 |doi=
*cite journal | author=Inaba T, Matsushime H, Valentine M, "et al." |title=Genomic organization, chromosomal localization, and independent expression of human cyclin D genes. |journal=Genomics |volume=13 |issue= 3 |pages= 565–74 |year= 1992 |pmid= 1386335 |doi=
*cite journal | author=Xiong Y, Menninger J, Beach D, Ward DC |title=Molecular cloning and chromosomal mapping of CCND genes encoding human D-type cyclins. |journal=Genomics |volume=13 |issue= 3 |pages= 575–84 |year= 1992 |pmid= 1386336 |doi=
*cite journal | author=Motokura T, Yi HF, Kronenberg HM, "et al." |title=Assignment of the human cyclin D3 gene (CCND3) to chromosome 6p----q13. |journal=Cytogenet. Cell Genet. |volume=61 |issue= 1 |pages= 5–7 |year= 1992 |pmid= 1387066 |doi=
*cite journal | author=Matsuoka S, Yamaguchi M, Matsukage A |title=D-type cyclin-binding regions of proliferating cell nuclear antigen. |journal=J. Biol. Chem. |volume=269 |issue= 15 |pages= 11030–6 |year= 1994 |pmid= 7908906 |doi=
*cite journal | author=Meyerson M, Harlow E |title=Identification of G1 kinase activity for cdk6, a novel cyclin D partner. |journal=Mol. Cell. Biol. |volume=14 |issue= 3 |pages= 2077–86 |year= 1994 |pmid= 8114739 |doi=
*cite journal | author=Dowdy SF, Hinds PW, Louie K, "et al." |title=Physical interaction of the retinoblastoma protein with human D cyclins. |journal=Cell |volume=73 |issue= 3 |pages= 499–511 |year= 1993 |pmid= 8490963 |doi=
*cite journal | author=Brooks AR, Shiffman D, Chan CS, "et al." |title=Functional analysis of the human cyclin D2 and cyclin D3 promoters. |journal=J. Biol. Chem. |volume=271 |issue= 15 |pages= 9090–9 |year= 1996 |pmid= 8621559 |doi=
*cite journal | author=Tiefenbrun N, Melamed D, Levy N, "et al." |title=Alpha interferon suppresses the cyclin D3 and cdc25A genes, leading to a reversible G0-like arrest. |journal=Mol. Cell. Biol. |volume=16 |issue= 7 |pages= 3934–44 |year= 1996 |pmid= 8668211 |doi=
*cite journal | author=Hirai H, Sherr CJ |title=Interaction of D-type cyclins with a novel myb-like transcription factor, DMP1. |journal=Mol. Cell. Biol. |volume=16 |issue= 11 |pages= 6457–67 |year= 1996 |pmid= 8887674 |doi=
*cite journal | author=Doglioni C, Chiarelli C, Macrí E, "et al." |title=Cyclin D3 expression in normal, reactive and neoplastic tissues. |journal=J. Pathol. |volume=185 |issue= 2 |pages= 159–66 |year= 1998 |pmid= 9713342 |doi= 10.1002/(SICI)1096-9896(199806)185:2<159::AID-PATH73>3.0.CO;2-0 |doilabel=10.1002/(SICI)1096-9896(199806)185:2159::AID-PATH733.0.CO;2-0
*cite journal | author=Gómez Lahoz E, Liegeois NJ, Zhang P, "et al." |title=Cyclin D- and E-dependent kinases and the p57(KIP2) inhibitor: cooperative interactions in vivo. |journal=Mol. Cell. Biol. |volume=19 |issue= 1 |pages= 353–63 |year= 1999 |pmid= 9858559 |doi=
*cite journal | author=Gabrielli BG, Sarcevic B, Sinnamon J, "et al." |title=A cyclin D-Cdk4 activity required for G2 phase cell cycle progression is inhibited in ultraviolet radiation-induced G2 phase delay. |journal=J. Biol. Chem. |volume=274 |issue= 20 |pages= 13961–9 |year= 1999 |pmid= 10318807 |doi=
*cite journal | author=Zhang Q, Wang X, Wolgemuth DJ |title=Developmentally regulated expression of cyclin D3 and its potential in vivo interacting proteins during murine gametogenesis. |journal=Endocrinology |volume=140 |issue= 6 |pages= 2790–800 |year= 1999 |pmid= 10342870 |doi=
*cite journal | author=Bartkova J, Rajpert-de Meyts E, Skakkebaek NE, Bartek J |title=D-type cyclins in adult human testis and testicular cancer: relation to cell type, proliferation, differentiation, and malignancy. |journal=J. Pathol. |volume=187 |issue= 5 |pages= 573–81 |year= 2000 |pmid= 10398124 |doi= 10.1002/(SICI)1096-9896(199904)187:5<573::AID-PATH289>3.0.CO;2-H |doilabel=10.1002/(SICI)1096-9896(199904)187:5573::AID-PATH2893.0.CO;2-H
*cite journal | author=Jones CJ, Kipling D, Morris M, "et al." |title=Evidence for a telomere-independent "clock" limiting RAS oncogene-driven proliferation of human thyroid epithelial cells. |journal=Mol. Cell. Biol. |volume=20 |issue= 15 |pages= 5690–9 |year= 2000 |pmid= 10891505 |doi=
*cite journal | author=Sansal I, Dupont E, Toru D, "et al." |title=NPDC-1, a regulator of neural cell proliferation and differentiation, interacts with E2F-1, reduces its binding to DNA and modulates its transcriptional activity. |journal=Oncogene |volume=19 |issue= 43 |pages= 5000–9 |year= 2000 |pmid= 11042687 |doi= 10.1038/sj.onc.1203843
*cite journal | author=Fink JR, LeBien TW |title=Novel expression of cyclin-dependent kinase inhibitors in human B-cell precursors. |journal=Exp. Hematol. |volume=29 |issue= 4 |pages= 490–8 |year= 2001 |pmid= 11301189 |doi=
*cite journal | author=Lin J, Jinno S, Okayama H |title=Cdk6-cyclin D3 complex evades inhibition by inhibitor proteins and uniquely controls cell's proliferation competence. |journal=Oncogene |volume=20 |issue= 16 |pages= 2000–9 |year= 2001 |pmid= 11360184 |doi= 10.1038/sj.onc.1204375
*cite journal | author=Bartkova J, Thullberg M, Slezak P, "et al." |title=Aberrant expression of G1-phase cell cycle regulators in flat and exophytic adenomas of the human colon. |journal=Gastroenterology |volume=120 |issue= 7 |pages= 1680–8 |year= 2001 |pmid= 11375949 |doi=

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