F13A1

Coagulation factor XIII, A1 polypeptide, also known as F13A1, is a human gene.

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summary_text = This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. [cite web | title = Entrez Gene: F13A1 coagulation factor XIII, A1 polypeptide| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2162| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Adány R |title=Intracellular factor XIII: cellular distribution of factor XIII subunit a in humans. |journal=Semin. Thromb. Hemost. |volume=22 |issue= 5 |pages= 399–408 |year= 1997 |pmid= 8989823 |doi=
*cite journal | author=Adány R, Bárdos H |title=Factor XIII subunit A as an intracellular transglutaminase. |journal=Cell. Mol. Life Sci. |volume=60 |issue= 6 |pages= 1049–60 |year= 2003 |pmid= 12861374 |doi= 10.1007/s00018-003-2178-9
*cite journal | author=Bereczky Z, Katona E, Muszbek L |title=Fibrin stabilization (factor XIII), fibrin structure and thrombosis. |journal=Pathophysiol. Haemost. Thromb. |volume=33 |issue= 5-6 |pages= 430–7 |year= 2005 |pmid= 15692256 |doi= 10.1159/000083841
*cite journal | author=Board P, Coggan M, Miloszewski K |title=Identification of a point mutation in factor XIII A subunit deficiency. |journal=Blood |volume=80 |issue= 4 |pages= 937–41 |year= 1992 |pmid= 1353995 |doi=
*cite journal | author=Kamura T, Okamura T, Murakawa M, "et al." |title=Deficiency of coagulation factor XIII A subunit caused by the dinucleotide deletion at the 5' end of exon III. |journal=J. Clin. Invest. |volume=90 |issue= 2 |pages= 315–9 |year= 1992 |pmid= 1644910 |doi=
*cite journal | author=Harsfalvi J, Fesus L, Tarcsa E, "et al." |title=The presence of a covalently cross-linked matrix in human platelets. |journal=Biochim. Biophys. Acta |volume=1073 |issue= 2 |pages= 268–74 |year= 1991 |pmid= 2009280 |doi=
*cite journal | author=Bishop PD, Teller DC, Smith RA, "et al." |title=Expression, purification, and characterization of human factor XIII in Saccharomyces cerevisiae. |journal=Biochemistry |volume=29 |issue= 7 |pages= 1861–9 |year= 1990 |pmid= 2184890 |doi=
*cite journal | author=Hilgenfeld R, Liesum A, Storm R, "et al." |title=Crystallization of blood coagulation factor XIII by an automated procedure. |journal=FEBS Lett. |volume=265 |issue= 1-2 |pages= 110–2 |year= 1990 |pmid= 2365049 |doi=
*cite journal | author=Carrell NA, Erickson HP, McDonagh J |title=Electron microscopy and hydrodynamic properties of factor XIII subunits. |journal=J. Biol. Chem. |volume=264 |issue= 1 |pages= 551–6 |year= 1989 |pmid= 2491853 |doi=
*cite journal | author=Takahashi N, Takahashi Y, Putnam FW |title=Primary structure of blood coagulation factor XIIIa (fibrinoligase, transglutaminase) from human placenta. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=83 |issue= 21 |pages= 8019–23 |year= 1986 |pmid= 2877456 |doi=
*cite journal | author=Grundmann U, Amann E, Zettlmeissl G, Küpper HA |title=Characterization of cDNA coding for human factor XIIIa. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=83 |issue= 21 |pages= 8024–8 |year= 1986 |pmid= 2877457 |doi=
*cite journal | author=Ichinose A, Davie EW |title=Characterization of the gene for the a subunit of human factor XIII (plasma transglutaminase), a blood coagulation factor. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=85 |issue= 16 |pages= 5829–33 |year= 1988 |pmid= 2901091 |doi=
*cite journal | author=Board PG, Webb GC, McKee J, Ichinose A |title=Localization of the coagulation factor XIII A subunit gene (F13A) to chromosome bands 6p24----p25. |journal=Cytogenet. Cell Genet. |volume=48 |issue= 1 |pages= 25–7 |year= 1988 |pmid= 2903011 |doi=
*cite journal | author=Ichinose A, Hendrickson LE, Fujikawa K, Davie EW |title=Amino acid sequence of the a subunit of human factor XIII. |journal=Biochemistry |volume=25 |issue= 22 |pages= 6900–6 |year= 1987 |pmid= 3026437 |doi=
*cite journal | author=Takagi T, Doolittle RF |title=Amino acid sequence studies on factor XIII and the peptide released during its activation by thrombin. |journal=Biochemistry |volume=13 |issue= 4 |pages= 750–6 |year= 1974 |pmid= 4811064 |doi=
*cite journal | author=Yee VC, Pedersen LC, Bishop PD, "et al." |title=Structural evidence that the activation peptide is not released upon thrombin cleavage of factor XIII. |journal=Thromb. Res. |volume=78 |issue= 5 |pages= 389–97 |year= 1995 |pmid= 7660355 |doi=
*cite journal | author=Coggan M, Baker R, Miloszewski K, "et al." |title=Mutations causing coagulation factor XIII subunit A deficiency: characterization of the mutant proteins after expression in yeast. |journal=Blood |volume=85 |issue= 9 |pages= 2455–60 |year= 1995 |pmid= 7727776 |doi=
*cite journal | author=Kaczmarek E, Liu Y, Berse B, "et al." |title=Biosynthesis of plasma factor XIII: evidence for transcription and translation in hepatoma cells. |journal=Biochim. Biophys. Acta |volume=1247 |issue= 1 |pages= 127–34 |year= 1995 |pmid= 7873582 |doi=
*cite journal | author=Yee VC, Pedersen LC, Le Trong I, "et al." |title=Three-dimensional structure of a transglutaminase: human blood coagulation factor XIII. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 15 |pages= 7296–300 |year= 1994 |pmid= 7913750 |doi=
*cite journal | author=Suzuki K, Iwata M, Ito S, "et al." |title=Molecular basis for subtypic differences of the "a" subunit of coagulation factor XIII with description of the genesis of the subtypes. |journal=Hum. Genet. |volume=94 |issue= 2 |pages= 129–35 |year= 1994 |pmid= 7913909 |doi=

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