Isoguanine

Isoguanine

Chembox new
ImageFile=Isoguanine.pngImageSize=150px
IUPACName=6-Amino-1,7-dihydropurin-2-one
OtherNames=2-Hydroxyadenine
Section1= Chembox Identifiers
CASNo=3373-53-3
PubChem=76900
EINEC=222-157-6
SMILES=C1=NC2=NC(=O)NC(=C2N1)N
Section2= Chembox Properties
Formula=C5H5N5O
MolarMass=151.1261
Appearance=
Density=
MeltingPt=
BoilingPt=
Solubility=
Section3= Chembox Hazards
MainHazards=
FlashPt=
Autoignition=

Isoguanine or 2-hydroxyladenine is a purine base that is an isomer of guanine. It is a product of oxidative damage to DNA and has been shown to cause mutation. [cite journal |author=Yang XL, Sugiyama H, Ikeda S, Saito I, Wang AH |title=Structural studies of a stable parallel-stranded DNA duplex incorporating isoguanine:cytosine and isocytosine:guanine basepairs by nuclear magnetic resonance spectroscopy |journal=Biophys. J. |volume=75 |issue=3 |pages=1163–71 |year=1998 |pmid=9726918 |doi=] It is also used in combination with isocytosine in studies of unnatural nucleic acid analogues of the normal base pairs in DNA.

References


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