Isoguanine

Isoguanine

Chembox new
ImageFile=Isoguanine.pngImageSize=150px
IUPACName=6-Amino-1,7-dihydropurin-2-one
OtherNames=2-Hydroxyadenine
Section1= Chembox Identifiers
CASNo=3373-53-3
PubChem=76900
EINEC=222-157-6
SMILES=C1=NC2=NC(=O)NC(=C2N1)N
Section2= Chembox Properties
Formula=C5H5N5O
MolarMass=151.1261
Appearance=
Density=
MeltingPt=
BoilingPt=
Solubility=
Section3= Chembox Hazards
MainHazards=
FlashPt=
Autoignition=

Isoguanine or 2-hydroxyladenine is a purine base that is an isomer of guanine. It is a product of oxidative damage to DNA and has been shown to cause mutation. [cite journal |author=Yang XL, Sugiyama H, Ikeda S, Saito I, Wang AH |title=Structural studies of a stable parallel-stranded DNA duplex incorporating isoguanine:cytosine and isocytosine:guanine basepairs by nuclear magnetic resonance spectroscopy |journal=Biophys. J. |volume=75 |issue=3 |pages=1163–71 |year=1998 |pmid=9726918 |doi=] It is also used in combination with isocytosine in studies of unnatural nucleic acid analogues of the normal base pairs in DNA.

References


Wikimedia Foundation. 2010.

Игры ⚽ Поможем написать курсовую

Look at other dictionaries:

  • Purine — chembox ImageFile=Purine chemical structure.png ImageSize= 345px ImageFile2= IUPACName=7H purine OtherNames= Section1= Chembox Identifiers CASNo=120 73 0 PubChem=1044 ChemSpiderID = 1015 SMILES=C1=C2C(=NC=N1)N=CN2 MeSHName=Purine Section2=… …   Wikipedia

  • Nucleobase — Base pairing in RNA. Nucleobases in blue. Hydrogen bonds in red. Nucleobases are a group of nitrogen based molecules that are required to form nucleotides, the basic building blocks of DNA and RNA. Nucleobases provide the molecular structure… …   Wikipedia

  • Nucleic acid analogues — Not to be confused with degenerate bases. For phosphoramidite synthesis of nucleic acids, see Oligonucleotide synthesis. RNA with its nucleobases to the left and DNA to the right. Nucleic acid analogues are compounds structurally similar (analog) …   Wikipedia

  • Isocytosine — Chembox new ImageFile=Isocytosine.png ImageSize=120px IUPACName=2 Amino 3H pyrimidin 4 one OtherNames=2 Aminouracil Section1= Chembox Identifiers CASNo=108 53 2 PubChem=66950 SMILES=C1=CN=C(NC1=O)N Section2= Chembox Properties Formula=C4H5N3O… …   Wikipedia

Share the article and excerpts

Direct link
… Do a right-click on the link above
and select “Copy Link”