- SMARCA4
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4, also known as SMARCA4, is a human
gene .PBB_Summary
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summary_text = The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. [cite web | title = Entrez Gene: SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6597| accessdate = ] Recently a high percent of inactivation of this gene has been found in human lung cancer cell lines (2).References
(2) Frequent BRG1/SMARCA4-inactivating mutations in human lung cancer cell lines. Hum Mutat. 2008 Apr 3;
Further reading
Involvement of the Chromatin-Remodeling Factor BRG1/SMARCA4 in Human Cancer.Epigenetics. 2008 Apr 17;3(2)
*cite journal | author=Voellmy R |title=Sensing stress and responding to stress. |journal=EXS |volume=77 |issue= |pages= 121–37 |year= 1996 |pmid= 8856972 |doi=
*cite journal | author=Peterson CL |title=Chromatin remodeling: nucleosomes bulging at the seams. |journal=Curr. Biol. |volume=12 |issue= 7 |pages= R245–7 |year= 2002 |pmid= 11937040 |doi=PBB_Controls
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