- PRKDC
Protein kinase, DNA-activated, catalytic polypeptide, also known as PRKDC, is a human
gene .PBB_Summary
section_title =
summary_text = The PRKDC gene encodes the catalytic subunit of a nuclear DNA-dependent serine/threonine protein kinase (DNA-PK). The second component is the autoimmune antigen Ku (MIM 152690), which is encoded by the G22P1 gene on chromosome 22q. On its own, the catalytic subunit of DNA-PK is inactive and relies on the G22P1 component to direct it to the DNA and trigger its kinase activity; PRKDC must be bound to DNA to express its catalytic properties. [supplied by OMIM] [cite web | title = Entrez Gene: PRKDC protein kinase, DNA-activated, catalytic polypeptide| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5591| accessdate = ]ee also
*
Protein kinase References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Giaccia AJ, Kastan MB |title=The complexity of p53 modulation: emerging patterns from divergent signals. |journal=Genes Dev. |volume=12 |issue= 19 |pages= 2973–83 |year= 1998 |pmid= 9765199 |doi=
*cite journal | author=Collis SJ, DeWeese TL, Jeggo PA, Parker AR |title=The life and death of DNA-PK. |journal=Oncogene |volume=24 |issue= 6 |pages= 949–61 |year= 2005 |pmid= 15592499 |doi= 10.1038/sj.onc.1208332
*cite journal | author=Van Maele B, Debyser Z |title=HIV-1 integration: an interplay between HIV-1 integrase, cellular and viral proteins. |journal=AIDS reviews |volume=7 |issue= 1 |pages= 26–43 |year= 2005 |pmid= 15875659 |doi=PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes
Wikimedia Foundation. 2010.
