- FHIT
Fragile histidine triad gene, also known as FHIT, is a human
gene .PBB_Summary
section_title =
summary_text = This gene, a member of the histidine triad gene family, encodes a diadenosine 5',5"' -P1,P3-triphosphate hydrolase involved in purine metabolism. The gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts of this gene. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. [cite web | title = Entrez Gene: FHIT fragile histidine triad gene| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2272| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Bianchi F, Tagliabue E, Ménard S, Campiglio M |title=Fhit expression protects against HER2-driven breast tumor development: unraveling the molecular interconnections. |journal=Cell Cycle |volume=6 |issue= 6 |pages= 643–6 |year= 2007 |pmid= 17374991 |doi=PBB_Controls
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