- 7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase
In
enzymology , a 7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase (EC number|1.14.13.95) is anenzyme that catalyzes thechemical reaction :7alpha-hydroxycholest-4-en-3-one + NADPH + H+ + O2 7alpha,12alpha-dihydroxycholest-4-en-3-one + NADP+ + H2O
The 4 substrates of this enzyme are
7alpha-hydroxycholest-4-en-3-one , NADPH, H+, and O2, whereas its 3 products are7alpha,12alpha-dihydroxycholest-4-en-3-one , NADP+, and H2O.This enzyme belongs to the family of
oxidoreductase s, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with NADH or NADPH as one donor, and incorporation of one atom o oxygen into the other donor. The systematic name of this enzyme class is 7alpha-hydroxycholest-4-en-3-one,NADPH:oxygen oxidoreductase (12alpha-hydroxylating). Other names in common use include 7alpha-hydroxy-4-cholesten-3-one 12alpha-monooxygenase, CYP12, sterol 12alpha-hydroxylase (ambiguous), and HCO 12alpha-hydroxylase. This enzyme participates inppar signaling pathway .References
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