Pyrroloquinoline-quinone synthase

In enzymology, a pyrroloquinoline-quinone synthase (EC number|1.3.3.11) is an enzyme that catalyzes the chemical reaction

:6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,5,6,7,8-octahydroquinoline-2,4-dicarboxylate + 3 O₂ $ightleftharpoons$ 4,5-dioxo-3a,4,5,6,7,8,9,9b-octahydro-1H-pyrrolo [2,3-f] quinoline- 2,7,9-tricarboxylate + 2 H₂O₂ + 2 H₂O

The two substrates of this enzyme are 6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,5,6,7,8-octahydroquinoline-2,4-dicarboxylate, and O₂, whereas its 3 products are 4,5-dioxo-3a,4,5,6,7,8,9,9b-octahydro-1H-pyrrolo [2,3-f] quinoline-2,7,9-tricarboxylate, H₂O₂, and H₂O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with oxygen as acceptor. The systematic name of this enzyme class is 6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,5,6,7,8-octahydroquinol ine-2,4-dicarboxylate:oxygen oxidoreductase (cyclizing). This enzyme is also called PqqC.

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