CCNT1

Cyclin T1, also known as CCNT1, is a human gene.

PBB_Summary
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summary_text = The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin tightly associates with CDK9 kinase, and was found to be a major subunit of the transcription elongation factor p-TEFb. The kinase complex containing this cyclin and the elongation factor can interact with, and act as a cofactor of human immunodeficiency virus type 1 (HIV-1) Tat protein, and was shown to be both necessary and sufficient for full activation of viral transcription. This cyclin and its kinase partner were also found to be involved in the phosphorylation and regulation of the carboxy-terminal domain (CTD) of the largest RNA polymerase II subunit. [cite web | title = Entrez Gene: CCNT1 cyclin T1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=904| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Jeang KT |title=Tat, Tat-associated kinase, and transcription. |journal=J. Biomed. Sci. |volume=5 |issue= 1 |pages= 24–7 |year= 1998 |pmid= 9570510 |doi=
*cite journal | author=Yankulov K, Bentley D |title=Transcriptional control: Tat cofactors and transcriptional elongation. |journal=Curr. Biol. |volume=8 |issue= 13 |pages= R447–9 |year= 1998 |pmid= 9651670 |doi=
*cite journal | author=Romano G, Kasten M, De Falco G, "et al." |title=Regulatory functions of Cdk9 and of cyclin T1 in HIV tat transactivation pathway gene expression. |journal=J. Cell. Biochem. |volume=75 |issue= 3 |pages= 357–68 |year= 2000 |pmid= 10536359 |doi=
*cite journal | author=Cunningham AL, Li S, Juarez J, "et al." |title=The level of HIV infection of macrophages is determined by interaction of viral and host cell genotypes. |journal=J. Leukoc. Biol. |volume=68 |issue= 3 |pages= 311–7 |year= 2000 |pmid= 10985245 |doi=
*cite journal | author=Marcello A, Zoppé M, Giacca M |title=Multiple modes of transcriptional regulation by the HIV-1 Tat transactivator. |journal=IUBMB Life |volume=51 |issue= 3 |pages= 175–81 |year= 2002 |pmid= 11547919 |doi=
*cite journal | author=Huigen MC, Kamp W, Nottet HS |title=Multiple effects of HIV-1 trans-activator protein on the pathogenesis of HIV-1 infection. |journal=Eur. J. Clin. Invest. |volume=34 |issue= 1 |pages= 57–66 |year= 2004 |pmid= 14984439 |doi=
*cite journal | author=Rice AP, Herrmann CH |title=Regulation of TAK/P-TEFb in CD4+ T lymphocytes and macrophages. |journal=Curr. HIV Res. |volume=1 |issue= 4 |pages= 395–404 |year= 2004 |pmid= 15049426 |doi=
*cite journal | author=Minghetti L, Visentin S, Patrizio M, "et al." |title=Multiple actions of the human immunodeficiency virus type-1 Tat protein on microglial cell functions. |journal=Neurochem. Res. |volume=29 |issue= 5 |pages= 965–78 |year= 2004 |pmid= 15139295 |doi=
*cite journal | author=Kino T, Pavlakis GN |title=Partner molecules of accessory protein Vpr of the human immunodeficiency virus type 1. |journal=DNA Cell Biol. |volume=23 |issue= 4 |pages= 193–205 |year= 2004 |pmid= 15142377 |doi= 10.1089/104454904773819789
*cite journal | author=Liou LY, Herrmann CH, Rice AP |title=HIV-1 infection and regulation of Tat function in macrophages. |journal=Int. J. Biochem. Cell Biol. |volume=36 |issue= 9 |pages= 1767–75 |year= 2005 |pmid= 15183343 |doi= 10.1016/j.biocel.2004.02.018
*cite journal | author=Pugliese A, Vidotto V, Beltramo T, "et al." |title=A review of HIV-1 Tat protein biological effects. |journal=Cell Biochem. Funct. |volume=23 |issue= 4 |pages= 223–7 |year= 2005 |pmid= 15473004 |doi= 10.1002/cbf.1147
*cite journal | author=Bannwarth S, Gatignol A |title=HIV-1 TAR RNA: the target of molecular interactions between the virus and its host. |journal=Curr. HIV Res. |volume=3 |issue= 1 |pages= 61–71 |year= 2005 |pmid= 15638724 |doi=
*cite journal | author=Gibellini D, Vitone F, Schiavone P, Re MC |title=HIV-1 tat protein and cell proliferation and survival: a brief review. |journal=New Microbiol. |volume=28 |issue= 2 |pages= 95–109 |year= 2005 |pmid= 16035254 |doi=
*cite journal | author=Peruzzi F |title=The multiple functions of HIV-1 Tat: proliferation versus apoptosis. |journal=Front. Biosci. |volume=11 |issue= |pages= 708–17 |year= 2006 |pmid= 16146763 |doi=

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