Protein-S-isoprenylcysteine O-methyltransferase

In enzymology, a protein-S-isoprenylcysteine O-methyltransferase (EC number|2.1.1.100) is an enzyme that catalyzes the chemical reaction

:S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine $ightleftharpoons$ S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester

Thus, the two substrates of this enzyme are S-adenosyl methionine and protein C-terminal S-farnesyl-L-cysteine, whereas its two products are S-adenosylhomocysteine and protein C-terminal S-farnesyl-L-cysteine methyl ester.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:protein-C-terminal-S-farnesyl-L-cysteine O-methyltransferase. Other names in common use include farnesyl cysteine C-terminal methyltransferase, farnesyl-protein carboxymethyltransferase, protein C-terminal farnesylcysteine O-methyltransferase, farnesylated protein C-terminal O-methyltransferase, isoprenylated protein methyltransferase, prenylated protein methyltransferase, protein S-farnesylcysteine C-terminal methyltransferase, S-farnesylcysteine methyltransferase, prenylcysteine carboxylmethyltransferase [misleading] , prenylcysteine carboxymethyltransferase [misleading] , and prenylcysteine methyltransferase.

References

*
*
*

External links

::"The CAS registry number for this enzyme class is CAS registry|130731-20-3."

Gene Ontology (GO) codes