MRNA (guanine-N7-)-methyltransferase
- MRNA (guanine-N7-)-methyltransferase
In enzymology, a mRNA (guanine-N7-)-methyltransferase (EC number|2.1.1.56) is an enzyme that catalyzes the chemical reaction
:S-adenosyl-L-methionine + G(5')pppR-RNA S-adenosyl-L-homocysteine + m7G(5')pppR-RNA (mRNA containing an N7-methylguanine cap)
Thus, the two substrates of this enzyme are S-adenosyl methionine and G(5')pppR-RNA, whereas its two products are S-adenosylhomocysteine and m7G(5')pppR-RNA.
This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:mRNA (guanine-N7-)-methyltransferase. Other names in common use include messenger ribonucleate guanine 7-methyltransferase, guanine-7-methyltransferase, messenger RNA guanine 7-methyltransferase, and S-adenosyl-L-methionine:mRNA (guanine-7-N-)-methyltransferase.
tructural studies
As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes PDB link|1Z3C and PDB link|2HV9.
References
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External links
::"The CAS registry number for this enzyme class is CAS registry|56941-25-4."
Gene Ontology (GO) codes
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